Epidemiological characterization of Plasmodium falciparum in the Republic of Cabo Verde:: implications for potential large-scale re-emergence of malaria
Epidemiological characterization of Plasmodium falciparum in the Republic of Cabo Verde:: implications for potential large-scale re-emergence of malaria
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DOI：
10.1186/1475-2875-5-32
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发表时间：
2006-04-21
期刊：
影响因子：
3
通讯作者：
Arez, Ana Paula
中科院分区：
文献类型：
--
作者：
Alves, Joana;Roque, Ana Luisa;Arez, Ana Paula
背景：1970年，卡波维德群岛的疟疾已接近根除。现在只在发生疫情的圣地亚哥观察到感染。在这些岛屿上，国际社会认为疟疾风险有限，因此不建议采取预防措施。由于了解疟疾暴发的决定因素对控制疟疾至关重要，因此本研究旨在调查圣地亚哥岛观察到的疟疾感染是否维持在孤立的疫源地和无症状的个体中。方法：采用PCR和血清学分析方法调查有疟疾史的村庄中无症状携带者的发生率以及这些人群的暴露水平。结果表明，疟疾是保持无症状和亚专利感染，大多数的循环寄生虫种群港口氯喹耐药mutations.Conclusion：这些意见突出了令人震惊的疟疾成为一个严重的公共卫生问题的前景，并强调需要更严格的监测。
Background: Malaria has come near eradication at archipelago of Cabo Verde in 1970. Infections are now only observed in Santiago, where outbreaks occur. In these islands, malaria is considered by the international community as being of limited risk and, therefore, no prophylaxis is recommended. Since the understanding of factors that determine malaria outbreaks are crucial for controlling the disease, the present study aimed to investigate if the malaria infections observed in Santiago Island are maintained in isolated foci and in asymptomatic individuals.Methods: The occurrence of asymptomatic carriers in villages with history of malaria as well as the level of exposure of these populations were investigated using PCR and serological analyses.Results: Results indicate that malaria is maintained as asymptomatic and sub-patent infections and that the majority of the circulating parasite populations harbour chloroquine-resistant mutations.Conclusion: These observations highlight the alarming prospect of malaria to become a serious public health problem and underscore the need for a tighter surveillance.