TGF-β Activation and Signaling in Angiogenesis
TGF-β Activation and Signaling in Angiogenesis
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DOI：
10.5772/66405
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
McCarty, Joseph H.
中科院分区：
文献类型：
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作者：
Guerrero, Paola A.;McCarty, Joseph H.
The transforming growth factor-beta (TGF-beta) signaling pathway regulates various cellular processes during tissue and organ development and homeostasis. Deregulation of the expression and/or functions of TGF-beta ligands, receptors or their intracellular signaling components leads to multiple diseases including vascular pathologies, autoimmune disorders, fibrosis and cancer. In vascular development, physiology and disease TGF-beta signaling can have angiogenic and angiostatic properties, depending on expression levels and the tissue context. The objective of this chapter is to analyze the mechanisms that contribute to the activation and signaling of TGF-beta in developmental, physiological and pathological angiogenesis, with a particular emphasis on the importance of TGF-beta signaling in the mammalian central nervous system (CNS).
