Developments in T-cell depletion of allogeneic stem cell grafts
Developments in T-cell depletion of allogeneic stem cell grafts
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DOI：
10.1097/00062752-200011000-00005
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发表时间：
2000-11-01
影响因子：
3.2
通讯作者：
Löwenberg, B
中科院分区：
文献类型：
--
作者：
Cornelissen, JJ;Löwenberg, B
长期以来，T细胞的定量耗竭已被确立为预防移植物抗宿主病的高效方法。与T细胞耗竭（TCD）相关的缺点，包括移植物抗白血病效应的丧失和受损的免疫恢复已经成为更广泛应用的重要缺点。然而，最近，新的方法，如外周血干细胞的使用和TCD的应用，结合延迟供体淋巴细胞输注，开辟了新的可能性。第一个临床研究解决这些方法的优点表明，有效的预防移植物抗宿主病可以通过TCD实现，而移植物抗白血病的效果可以通过延迟供体淋巴细胞输注来维持。此外，免疫恢复可以通过使用外周血干细胞来加速。正在开发体外操作干细胞移植物的新技术，其目的是选择性地删除同种异体抗原特异性T细胞或通过阻断共刺激途径使此类T细胞耐受。因此，同种异体干细胞移植物的T细胞的体外操作目前享有新的科学兴趣。Curr Opin Hematol 2000，7：348-352（C）2000 Lippincott威廉姆斯& Wilkins，Inc.
The quantitative depletion of T-cells has long been established as a highly effective way to prevent graft-versus-host disease. The disadvantages associated with T-cel[ depletion (TCD), including loss of the graft-versus-leukemia effect and impaired immune recovery have been important drawbacks for application on a wider scale. Recently, however, new approaches such as the use of peripheral blood stem cells and the application of TCD, in conjunction with delayed donor lymphocyte infusion, have opened new possibilities. The first clinical studies addressing the merits of these approaches suggest that effective prevention of graft-versus-host disease may be achieved by TCD, whereas the graft-versus-leukemia effect may be maintained by delayed donor lymphocyte infusion. Also, immune recovery may be accelerated by the use of peripheral blood stem cells. New techniques to manipulate stem cell grafts in vitro are being developed with the purpose to either selectively delete alloantigen specific T cells or tolerize such T cells by blocking costimulatory pathways. As a result, the in vitro manipulation of T cells of allogeneic stem cell grafts currently enjoys renewed scientific interest. Curr Opin Hematol 2000, 7:348-352 (C) 2000 Lippincott Williams & Wilkins, Inc.