Hemoglobin-mediated nitric oxide signaling.
Hemoglobin-mediated nitric oxide signaling.
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DOI：
10.1016/j.freeradbiomed.2013.04.028
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发表时间：
2013-08
影响因子：
7.4
通讯作者：
Kim-Shapiro, Daniel B.
中科院分区：
文献类型：
--
作者：
Helms, Christine;Kim-Shapiro, Daniel B.
血红蛋白与一氧化氮（NO）反应的速度受到一氧化氮扩散到血红素口袋的速度的限制。这个反应和任何配体/蛋白质反应一样快，当血红蛋白处于氧合状态时，结果是硝酸盐的形成，这就是所谓的双氧合反应。由于硝酸盐在双氧反应中产生的浓度是生物惰性的，血红蛋白曾经被认为在NO信号传导中发挥的唯一作用是抑制它。然而，现在已经发现了血红蛋白可以保存、控制甚至产生NO活性的几种机制。这些机制包括反应物质的区隔化和一氧化氮从其他物质（如亚硝基硫醇或亚硝酸盐）中转化或转化为可以运输一氧化氮活性的其他物质。尽管在这一领域投入了大量的工作，但关于NO活性保存的精确机制以及Hb是否以及如何产生NO活性的主要问题仍然没有答案。
The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the result, when hemoglobin is in its oxygenated form, is formation of nitrate in what is known as the dioxygenation reaction. As nitrate, at the concentrations made through the dioxygenation reaction, is biologically inert, the only role hemoglobin was once thought to play in NO signaling was to inhibit it. However, there are now several mechanisms that have been discovered by which hemoglobin may preserve, control, and even create NO activity. These mechanisms involve compartmentalization of reacting species and conversion of NO from or into other species such as nitrosothiols or nitrite which could transport NO activity. Despite the tremendous amount of work devoted to this field, major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain unanswered.
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影响因子：
5.6
作者：
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通讯作者：
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DOI：
10.1073/pnas.0600942103
发表时间：
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影响因子：
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