CNS injection of CCK in rats: effects on real and sham feeding and gastric emptying.
CNS injection of CCK in rats: effects on real and sham feeding and gastric emptying.
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大鼠中枢神经系统注射 CCK：对真实和假喂养和胃排空的影响。
DOI：
10.1152/ajpregu.1990.258.5.r1165
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Baile,CA
中科院分区：
文献类型：
--
作者：
Della-Fera,MA;Coleman,BD;Baile,CA
进食过程中从肠道释放的胆囊收缩素（CCK）可能在饱腹感方面具有生理作用。还有证据表明，含有 CCK 的中枢通路的激活参与了摄食行为的控制。本研究的目的是确定将 CCK-8 注射到大鼠侧脑室 (lv) 中是否会抑制假喂养 (SF) 和真实喂养 (RF)。具有lv导管和胃插管的大鼠在lv（0、0.05、0.5微克）或腹膜内（ip）（0、4微克/kg）注射CCK-8后，在插管打开（SF）或闭合（RF）的情况下进食流质饮食。 ip CCK-8 显着降低 RF 和 SF。 lv CCK-8后RF也以剂量相关的方式降低，但SF不受lv CCK-8影响。 ip CCK-8 后进食减少可能部分是由于其抑制胃排空率 (GER)。为了确定中枢神经系统（CNS）CCK是否也可能参与胃功能的控制，在lv（0、0.05、0.5微克）或腹膜内（0、4微克/kg）注射CCK-8后测量GER。 ip CCK-8后GER显着降低，但lv CCK-8对GER没有影响。尽管 CNS 和外周 CCK 肽系统都可能与饱腹感有关，但 CNS CCK 似乎依赖于同时发生的外周营养相关刺激来引起饱腹感。
Cholecystokinin (CCK) released from the intestine during feeding may have a physiological role in satiety. There is also evidence that activation of central CCK-containing pathways is involved in the control of feeding behavior. This study was carried out to determine whether CCK-8 administered into the lateral cerebral ventricles (lv) of rats suppresses both sham feeding (SF) and real feeding (RF). Rats with lv guides and gastric cannulas ate a liquid diet with cannulas open (SF) or closed (RF) after lv (0, 0.05, 0.5 micrograms) or intraperitoneal (ip) (0, 4 micrograms/kg) injection of CCK-8. Both RF and SF were significantly decreased by ip CCK-8. RF was also decreased in a dose-related manner after lv CCK-8, but SF was not affected by lv CCK-8. Decreased feeding after ip CCK-8 may be due in part to its suppression of gastric emptying rate (GER). To determine whether central nervous system (CNS) CCK might also be involved in the control of gastric function, GER was measured after lv (0, 0.05, 0.5 micrograms) or ip (0, 4 micrograms/kg) injection of CCK-8. GER was significantly decreased after ip CCK-8, but lv CCK-8 had no effect on GER. Although both CNS and peripheral CCK peptide systems may be involved in satiety, CNS CCK appears to depend on concurrent peripheral nutrient-related stimuli in eliciting satiety.