Laserlight cues for gait freezing in Parkinson's disease: An open-label study
Laserlight cues for gait freezing in Parkinson's disease: An open-label study
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DOI：
10.1016/j.parkreldis.2010.08.010
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发表时间：
2011-05-01
影响因子：
4.1
通讯作者：
Simon, D. K.
中科院分区：
文献类型：
--
作者：
Donovan, S.;Lim, C.;Simon, D. K.
步态冻结（FOG）和福尔斯是帕金森病（PD）患者残疾的主要原因，并且对药物的反应有限。我们在一项26例PD患者的开放标签研究中评估了视觉提示克服FOG的疗效。福尔斯频率的变化是次要结局指标。受试者接受了1-2个月的基线期，使用无视觉提示的手杖或步行者，随后1个月使用具有激光视觉提示的相同装置。激光视觉提示与FOG问卷（FOGQ）评分适度但显着的平均降低相关，为1.25 +/- 0.48（p = 0.0152，双尾配对t检验），与平均基线FOGQ评分18.8相比，改善了6.6%。在基线和随后的研究期间，在至少发生一次跌倒的受试者中，使用激光视觉提示，跌倒频率平均降低39.5 +/- 9.3%（p = 0.002;双尾单样本t检验，假设平均值为0）。虽然一些个体受试者可能受益，但所有受试者的定时步态测试（TGT）的总体平均表现没有显著变化。然而，在接受TGT重复测试的4名受试者中，1名受试者显示激光视觉提示的TGT性能平均改善50%（p = 0.005;双尾配对t检验）。这项开放标签研究为激光视觉提示在克服FOG和减少PD患者福尔斯跌倒方面的适度疗效提供了证据。(C)2010爱思唯尔有限公司保留所有权利。
Freezing of gait (FOG) and falls are major sources of disability for Parkinson's disease (PD) patients, and show limited responsiveness to medications. We assessed the efficacy of visual cues for overcoming FOG in an open-label study of 26 patients with PD. The change in the frequency of falls was a secondary outcome measure. Subjects underwent a 1-2 month baseline period of use of a cane or walker without visual cues, followed by 1 month using the same device with the laserlight visual cue. The laserlight visual cue was associated with a modest but significant mean reduction in FOG Questionnaire (FOGQ) scores of 1.25 +/- 0.48 (p = 0.0152, two-tailed paired t-test), representing a 6.6% improvement compared to the mean baseline FOGQ scores of 18.8. The mean reduction in fall frequency was 39.5 +/- 9.3% with the laserlight visual cue among subjects experiencing at least one fall during the baseline and subsequent study periods (p = 0.002; two-tailed one-sample t-test with hypothesized mean of 0). Though some individual subjects may have benefited, the overall mean performance on the timed gait test (TGT) across all subjects did not significantly change. However, among the 4 subjects who underwent repeated testing of the TGT, one showed a 50% mean improvement in TGT performance with the laserlight visual cue (p = 0.005; two-tailed paired t-test). This open-label study provides evidence for modest efficacy of a laserlight visual cue in overcoming FOG and reducing falls in PD patients. (C) 2010 Elsevier Ltd. All rights reserved.