Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.
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DOI：
10.3389/fphar.2011.00049
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发表时间：
2011
影响因子：
5.6
通讯作者：
Sonveaux P
中科院分区：
文献类型：
--
作者：
Porporato PE;Dhup S;Dadhich RK;Copetti T;Sonveaux P
癌症是一种代谢性疾病，是两个代谢方程的解：用有限的资源产生能量和满足增殖细胞的生物合成需要。当糖酵解与三羧酸循环中的氧化磷酸化解偶联时，这两个方程都得到了解决，这一过程被称为糖酵解开关。本文综述了癌症中糖酵解的主要分子事件。它从调节巴斯德效应允许短期适应缺氧开始，强调了缺氧诱导转录因子HIF-1在长期适应缺氧中的关键作用，并总结了目前有关有氧糖酵解（瓦尔堡效应）在癌细胞增殖中的必要参与的知识。基于糖酵解在恶性肿瘤中的重要作用，本文简要回顾了以糖酵解为靶点的最新抗癌治疗方法。
Cancer is a metabolic disease and the solution of two metabolic equations: to produce energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both equations are solved when glycolysis is uncoupled from oxidative phosphorylation in the tricarboxylic acid cycle, a process known as the glycolytic switch. This review addresses in a comprehensive manner the main molecular events accounting for high-rate glycolysis in cancer. It starts from modulation of the Pasteur Effect allowing short-term adaptation to hypoxia, highlights the key role exerted by the hypoxia-inducible transcription factor HIF-1 in long-term adaptation to hypoxia, and summarizes the current knowledge concerning the necessary involvement of aerobic glycolysis (the Warburg effect) in cancer cell proliferation. Based on the many observations positioning glycolysis as a central player in malignancy, the most advanced anticancer treatments targeting tumor glycolysis are briefly reviewed.
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DOI：
10.1016/s0360-3016(01)01630-3
发表时间：
2001-10-01
影响因子：
7
作者：
Brizel, DM;Schroeder, T;Mueller-Klieser, W
通讯作者：
Mueller-Klieser, W
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
6.4
作者：
Chiche, Johanna;Le Fur, Yann;Lutz, Norbert W.
通讯作者：
Lutz, Norbert W.
影响因子：
6.2
作者：
Bueno, Valquiria;Binet, Isabelle;Wood, Kathryn
通讯作者：
Wood, Kathryn