Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice
Concurrent environmental enrichment and chronic restraint stress: Effects on innate anxiety and depressive-like behavior in male adolescent mice
复制标题
同时环境丰富和慢性束缚应激：对雄性青春期小鼠先天焦虑和抑郁样行为的影响
DOI：
10.1002/jdn.10061
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发表时间：
2020
影响因子：
1.8
通讯作者：
Ma Yuanye
中科院分区：
文献类型：
--
作者：
Mao Yu;Chen Yanmei;Yang Xiaomi;Wang Jianhong;Ge Longjiao;Fu Juan;Sun Huaying;Ma Yuanye
青春期是对环境刺激既表现出脆弱性又表现出适应能力的时期。本研究探讨了环境丰富(EE)和束缚应激(RS)对青春期小鼠先天焦虑和类抑郁行为的共存效应。雄性ICR小鼠从青春期早期(出生后第30天)开始每天给予EE和RS(4h/d或8h/d)治疗2或4周，并在治疗结束后24小时评估情绪行为。8小时RS治疗4周可减少强迫游泳实验中的不动时间，显示抗抑郁药样作用。在两周的治疗中，8小时RS显著减少了在明暗盒子亮起的隔间中花费的时间，表明焦虑程度增加。这些结果表明，在本实验设计下，不同持续时间的RS处理对小鼠情绪相关行为有不同的影响，但EE和RS之间不存在交互作用。
Adolescence is a period that exhibits both vulnerability and adaptation to environmental stimulus. This study explored the co‐existence effect of environmental enrichment (EE) and restraint stress (RS) on innate anxiety and depressive‐like behavior in adolescent mice. Male ICR mice were treated with daily EE and RS (4 h/d or 8 h/d) for 2 or 4 weeks from early adolescence (postnatal day 30) and emotional behaviors were evaluated 24 h after the end of treatment. 4 weeks of 8 h RS treatment decreased immobility time in forced swimming test, demonstrating an antidepressant‐like effect. For 2 weeks of treatment, 8 h RS significantly reduced the time spent in the lighted compartment of the light‐dark box, indicating an increased anxiety level. These results show that under the present experimental design, RS treatment with different duration could have different effect on mice emotion‐related behavior, but there was no interaction between EE and RS.