Suprachoroidal drug delivery to the back of the eye using hollow microneedles.
Suprachoroidal drug delivery to the back of the eye using hollow microneedles.
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DOI：
10.1007/s11095-010-0271-y
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发表时间：
2011-01
影响因子：
3.7
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Patel, Samirkumar R.;Lin, Angela S. P.;Edelhauser, Henry F.;Prausnitz, Mark R.
在这项工作中，我们测试的假设，微针提供了一种微创的方法，将颗粒注入脉络膜上腔的药物输送到眼睛的后面。将单个中空微针插入巩膜中，并将纳米颗粒和微米颗粒悬浮液注入脉络膜上腔。实验在离体的整个兔、猪和人眼上进行。使用明场和荧光显微镜以及微计算机断层扫描对颗粒递送进行成像。已证明，微针可将磺酰罗丹明B以及纳米颗粒和微粒悬浮液递送到兔、猪和人眼的脉络膜上腔中。持续给药至35 μL。递送装置参数的优化显示微针长度、压力和粒度在确定成功递送到脉络膜上腔中起重要作用。800- 1，000 μm的针头长度和250-300 kPa的压力提供了最可靠的输送。第一次显示了微针将纳米颗粒和微粒悬浮液递送到兔、猪和人眼的脉络膜上腔中。这表明，微针可以提供一种微创方法，用于控制药物递送到眼睛后部。
In this work, we tested the hypothesis that microneedles provide a minimally invasive method to inject particles into the suprachoroidal space for drug delivery to the back of the eye. A single, hollow microneedle was inserted into the sclera, and infused nanoparticle and microparticle suspensions into the suprachoroidal space. Experiments were performed on whole rabbit, pig, and human eyes ex vivo. Particle delivery was imaged using brightfield and fluorescence microscopy as well as microcomputed tomography. Microneedles were shown to deliver sulforhodamine B as well as nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig, and human eyes. Volumes up to 35 μL were administered consistently. Optimization of the delivery device parameters showed that microneedle length, pressure, and particle size played an important role in determining successful delivery into the suprachoroidal space. Needle lengths of 800–1,000 μm and applied pressures of 250–300 kPa provided most reliable delivery. Microneedles were shown for the first time to deliver nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig and human eyes. This shows that microneedles may provide a minimally invasive method for controlled drug delivery to the back of the eye.
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影响因子：
5.5
作者：
Van Damme, Pierre;Oosterhuis-Kafeja, Froukje;Levin, Yotam
通讯作者：
Levin, Yotam
DOI：
10.1073/pnas.2331316100
发表时间：
2003-11-25
影响因子：
11.1
作者：
McAllister, DV;Wang, PM;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
4.2
作者：
Olsen, Timothy W.;Feng, Xiao;Cameron, J. Douglas
通讯作者：
Cameron, J. Douglas
影响因子：
3.7
作者：
Jiang, Jason;Moore, Jason S.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
4.4
作者：
Gilger, BC;Salmon, JH;Robinson, MR
通讯作者：
Robinson, MR