The role of the opioid system in binge eating disorder.
The role of the opioid system in binge eating disorder.
复制标题
DOI：
10.1017/s1092852915000668
复制
发表时间：
2015-12
期刊：
影响因子：
3.3
通讯作者：
Cottone P
中科院分区：
文献类型：
--
作者：
Giuliano C;Cottone P
暴食症的特征是在短时间内过度、无法控制地食用可口的食物。过量摄入可口的食物被认为是由享乐驱动的，而不是能量平衡机制。然而，奖励处理不仅包括完善的行动，一个关键组成部分是代表的预期阶段，旨在获得奖励。这一阶段受环境食物相关刺激的影响很大，即使在没有生理需求的情况下，这些刺激也能强烈地增强进食的欲望。阿片系统（内源性肽及其受体）与美味食物摄入的奖励方面密切相关，并且可能代表了参与享乐性暴饮暴食的关键系统。在这里，我们审查的证据表明，阿片系统也可以被视为一个系统，调节预期的激励过程之前，暴饮暴食享乐情节。
Binge eating disorder is characterized by excessive, uncontrollable consumption of palatable food within brief periods of time. Excessive intake of palatable food is thought to be driven by hedonic, rather than energy homeostatic mechanisms. However, reward processing does not only comprise consummatory actions; a key component is represented by the anticipatory phase directed at procuring the reward. This phase is highly influenced by environmental food-associated stimuli which can robustly enhance the desire to eat even in the absence of physiological needs. The opioid system (endogenous peptides and their receptors) has been strongly linked to the rewarding aspects of palatable food intake, and perhaps represents the key system involved in hedonic overeating. Here we review evidence suggesting that the opioid system can also be regarded as one of the systems regulating the anticipatory incentive processes preceding binge eating hedonic episodes.