Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome
Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome
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DOI：
10.1007/978-1-4939-0620-8_36
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发表时间：
2014-01-01
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影响因子：
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通讯作者：
Sakatani, Kaoru
中科院分区：
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作者：
Kamiyama, Yayumi;Fujita, Yukihiko;Sakatani, Kaoru
近红外光谱可以识别基于某些因素的各种大脑状况，例如氧合血红蛋白（oxy-Hb）。自2012年7月以来，我们一直在日本东京的Nihon University Itabashi医院试图确定日本直立不耐受（也称为直立失调）儿童自主神经功能的机制。共有23名年龄在7-16岁的儿童被诊断为体位性心动过速综合征（POTS），这是一种直立性失调的亚型。我们评估了额叶皮质活动的不对称性与自动神经系统之间的关系，并比较了在活动站立测试中左右额叶皮质的氧血红蛋白变化。我们观察到，在站立活动期间，额叶皮层的氧合血红蛋白减少。氧血红蛋白的变化不对称，左侧额叶皮层的下降明显大于右侧额叶皮层，提示POTS患者活动站立时的心动过速可能是由于右侧额叶皮层激活引起交感神经系统活动引起的。
Near-infrared spectroscopy enables recognition of various brain conditions based on certain factors, such as oxygenated hemoglobin (oxy-Hb). Since July 2012, we have been trying to determine the mechanisms of autonomic function in Japanese children with orthostatic intolerance (also called orthostatic dysregulation) in Nihon University Itabashi Hospital in Tokyo, Japan. A total of 23 children aged 7-16 years diagnosed with postural tachycardia syndrome (POTS), a subtype of orthostatic dysregulation, were enrolled in the study. We evaluated the relation between asymmetry in frontal cortex activity and the automatic nervous system and compared oxy-Hb changes in the right and left frontal cortices during an active standing test. We observed that during active standing oxy-Hb decreased in the frontal cortex. The oxy-Hb changes were asymmetrical, with a significantly larger decrease in the left frontal cortex than in the right frontal cortex, suggesting that tachycardia during active standing in POTS patients might be caused by activation of the right frontal cortex, which induces sympathetic nervous system activity.