Preparation of protein-silicate hybrids from polyamine intercalation of layered montmorillonite
Preparation of protein-silicate hybrids from polyamine intercalation of layered montmorillonite
复制标题
DOI：
10.1021/la062013h
复制
发表时间：
2007-02-13
期刊：
影响因子：
3.9
通讯作者：
Tsai, Wei-Cheng
中科院分区：
文献类型：
--
作者：
Lin, Jiang-Jen;Wei, Jiun-Chiou;Tsai, Wei-Cheng
Hybrids of the model BSA protein and layered silicate clay with d spacing of similar to 62 A were prepared from either direct or stepwise intercalation. The pristine montmorilloinite (Na+-MMT) was first modified by poly(oxyalkylene)-amine salts (POP- and POE-amine) of 2000 g/mol M-w to a gallery-expanded silicate (d spacing = 53 and 18 A, respectively), which became accessible for BSA protein embedding. Subsequent BSA substitution allowed the embedding of the protein into the layered clay galleries in an uncompressed conformation. The stepwise process of embedding large molecules into the silicate gallery provides a new method for synthesizing biomaterial/clay hybrids potentially useful in drug delivery or biomedical design.
