Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti‐Inflammatory Properties by Inhibiting L‐Selectin Binding and Complement Activation
Shell Cleavable Dendritic Polyglycerol Sulfates Show High Anti‐Inflammatory Properties by Inhibiting L‐Selectin Binding and Complement Activation
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DOI：
10.1002/adhm.201500503
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发表时间：
2015-08
影响因子：
10
通讯作者：
S. Reimann;D. Gröger;C. Kühne;Sebastian B. Riese;J. Dernedde;R. Haag
中科院分区：
文献类型：
--
作者：
S. Reimann;D. Gröger;C. Kühne;Sebastian B. Riese;J. Dernedde;R. Haag
通过将可降解的连接体引入到稳定的生物相容性树枝状聚甘油支架中并随后进行硫酸化来制备一类新的全合成壳可裂解的多价聚硫酸酯。硫酸化聚合物显示出不同的降解特征、低抗凝剂和高抗炎特性，能够有效地结合L-选择素并在体外以非常低的浓度抑制补体激活。
A new class of fully synthetic shell cleavable multivalent polysulfates is prepared by introducing degradable linkers into a stable biocompatible dendritic polyglycerol scaffold and subsequent sulfation. The sulfated polymers show different degradation profiles, low anticoagulant and high anti-inflammatory properties, are able to efficiently bind to L-selectin and inhibit the complement activation at very low concentrations in vitro.