Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives
Sleep spindles and slow waves in schizophrenia and related disorders: main findings, challenges and future perspectives
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DOI：
10.1111/ejn.13815
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发表时间：
2018-10-01
影响因子：
3.4
通讯作者：
D'Agostino, Armando
中科院分区：
文献类型：
--
作者：
Castelnovo, Anna;Graziano, Bianca;D'Agostino, Armando
睡眠异常最近重新引起了精神分裂症患者的关注。丘脑皮质脑振荡中断有望作为该疾病的假定生物标志物或内表型。尽管与睡眠纺锤波和慢波活动相关的研究有所增加，但研究结果仍然部分矛盾。虽然睡眠梭形缺陷已被证实在几组慢性，药物治疗的精神分裂症患者，数据的早期阶段的障碍和未用药的主题仍然是不够的。慢波异常的研究结果在很大程度上是不确定的，可能是由于不同的标准来定义的现象和非典型抗精神病药物的影响。在这篇综述中，我们的目标是解决方法和实际问题，可能限制了跨研究组和不同患者人群的研究结果的一致性。鉴于这些振荡的神经生物学相关性，反映了丘脑皮质和皮质-皮质功能的完整性，应鼓励在这一领域的研究。为了促进对这些睡眠相关现象的科学和临床意义的广泛共识，我们提倡统一和健全的方法。这些应包括脑电图记录和分析技术，但也选择标准和临床人群的特点。
Sleep abnormalities have recently gained renewed attention in patients diagnosed with schizophrenia. Disrupted thalamocortical brain oscillations hold promise as putative biomarkers or endophenotypes of the disorder. Despite an increase in studies related to sleep spindle and slow-wave activity, findings remain in part contradictory. Although sleep spindle deficits have been confirmed in several groups of patients with chronic, medicated schizophrenia, data on the early stages of the disorder and in unmedicated subjects are still insufficient. Findings on slow-wave abnormalities are largely inconclusive, possibly due to the different criteria employed to define the phenomenon and to the influence of atypical antipsychotics. In this review, we aim to address the methodological and practical issues that may have limited the consistency of findings across research groups and different patient populations. Given the neurobiological relevance of these oscillations, which reflect the integrity of thalamocortical and cortico-cortical function, research in this domain should be encouraged. To promote widespread consensus over the scientific and clinical implications of these sleep-related phenomena, we advocate uniform and sound methodological approaches. These should encompass electroencephalographic recording and analysis techniques but also selection criteria and characterization of clinical populations.