CENTRAL SEROTONERGIC NERVES PROJECT TO THE PIAL VESSELS OF THE BRAIN
CENTRAL SEROTONERGIC NERVES PROJECT TO THE PIAL VESSELS OF THE BRAIN
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DOI：
10.1038/306055a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
SCATTON, B
中科院分区：
文献类型：
--
作者：
EDVINSSON, L;DEGUEURCE, A;SCATTON, B
血清素与多种脑血管（循环）疾病的病因密切相关，包括中风、偏头痛和血管痉挛。先前的研究表明七鳃鳗的大脑动脉中存在血管周围神经的吲哚胺能系统1,2。此外，一些作者观察到，不同物种的脑动脉（例如兔子的椎基底动脉系统）和微血管可能会吸收血清素和 5-羟色氨酸3-6。然而，大脑动脉和微血管（主要是毛细血管）都不能直接控制或改变脑血流量；与其他血管床一样，小动脉和小动脉是主要的阻力元件。我们在这里使用免疫细胞化学和神经化学技术报告了大鼠软脑膜动脉和小动脉中枢血清素能神经支配的存在。这些纤维似乎具有中枢神经元起源，从中缝核和中缝背核发出。这种血管周围的血清素神经支配可能在脑循环的正常调节和病理条件下发挥作用。
Serotonin is strongly implicated in the aetiology of several cerebrovascular (circulatory) diseases, including stroke, migraine and vasospasm. Previous studies have suggested the existence of an indoleaminergic system of perivascular nerves in large cerebral arteries of the lamprey1,2. In addition, some authors have observed that cerebral arteries (such as the vertebrobasilar system of the rabbit) and microvessels may take up serotonin and 5-hydroxytryptophan in various species3–6. However, neither large cerebral arteries nor microvessels (primarily capillaries) directly control, or change, cerebral blood flow; as in other vascular beds, it is the arterioles and small arteries that are the major resistance elements. We report here on the presence of a central serotonergic innervation of pial arteries and arterioles in the rat, using immunocytochemical and neurochemical techniques. The fibres seem to have a central neuronal origin, emanating from both median and dorsal raphé nuclei. This perivascular serotonergic innervation may have a role both in the normal regulation of the cerebral circulation and in pathological conditions.