Myocardial perfusion assessment in the infarct core and penumbra zones in an in-vivo porcine model of the acute, sub-acute, and chronic infarction
Myocardial perfusion assessment in the infarct core and penumbra zones in an in-vivo porcine model of the acute, sub-acute, and chronic infarction
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DOI：
10.1007/s00330-020-07220-x
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发表时间：
2020-11
影响因子：
5.9
通讯作者：
M. Yang;Huayan Xu;Lu Zhang;Lin Chen;R. Xu;H. Fu;Hui Liu;Xue-Sheng Li;Chuan Fu;Keling Liu;Hong Li;Xiao-yue Zhou;Ying-kun Guo;Zhi-gang Yang
中科院分区：
文献类型：
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作者：
M. Yang;Huayan Xu;Lu Zhang;Lin Chen;R. Xu;H. Fu;Hui Liu;Xue-Sheng Li;Chuan Fu;Keling Liu;Hong Li;Xiao-yue Zhou;Ying-kun Guo;Zhi-gang Yang
ObjectivesTo assess the longitudinal changes of microvascular function in different myocardial regions after myocardial infarction (MI) using myocardial blood flow derived by dynamic CT perfusion (CTP-MBF), and compare CTP-MBF with the results of cardiac magnetic resonance (CMR) and histopathology.MethodsThe CTP scanning was performed in a MI porcine model 1 day (n= 15), 7 days (n= 10), and 3 months (n= 5) following induction surgery. CTP-MBF was measured in the infarcted myocardium, penumbra, and remote myocardium, respectively. CMR perfusion and histopathology were performed for validation.ResultsFrom baseline to follow-up scans, CTP-MBF presented a stepwise increase in the infarcted myocardium (68.51 ± 11.04 vs. 86.73 ± 13.32 vs. 109.53 ± 26.64 ml/100 ml/min,p= 0.001) and the penumbra (104.92 ± 29.29 vs. 120.32 ± 24.74 vs. 183.01 ± 57.98 ml/100 ml/min,p= 0.008), but not in the remote myocardium (150.05 ± 35.70 vs. 166.66 ± 38.17 vs. 195.36 ± 49.64 ml/100 ml/min,p= 0.120). The CTP-MBF correlated with max slope (r= 0.584,p< 0.001), max signal intensity (r= 0.357,p< 0.001), and time to max (r= − 0.378,p< 0.001) by CMR perfusion. Moreover, CTP-MBF defined the infarcted myocardium on triphenyl tetrazolium chloride staining (AUC: 0.810,p< 0.001) and correlated with microvascular density on CD31 staining (r= 0.561,p= 0.002).ConclusionCTP-MBF could quantify the longitudinal changes of microvascular function in different regions of the post-MI myocardium, which demonstrates good agreement with contemporary CMR and histopathological findings.Key Points• The CT perfusion–based myocardial blood flow (CTP-MBF) could quantify the microvascular impairment in different myocardial regions after myocardial infarction (MI) and track its recovery over time.• The assessment of CTP-MBF is in good agreement with contemporary cardiac MRI and histopathological findings, which potentially facilitates a rapid approach for pathophysiological insights following MI.
