Exploring the mechanisms of antigen processing by cell fractionation.
Exploring the mechanisms of antigen processing by cell fractionation.
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DOI：
10.1016/s0952-7915(98)80242-2
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发表时间：
1998-04
影响因子：
7
通讯作者：
P. Pierre;I. Mellman
中科院分区：
文献类型：
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作者：
P. Pierre;I. Mellman
越来越清楚的是，抗原呈递细胞中含有MHC II类产物的大多数细胞内区室仅代表在所有细胞类型中表达的常规内体和溶酶体。然而，从最近的细胞分级分离研究的数据，主要是那些使用电泳技术，表明人口的第二类含有囊泡的存在，可能包括一类内体，专门用于抗原加工。对这种可能性的有力支持来自于这样的观察，即指定为II类囊泡（CIV）的这种专门结构在成熟树突细胞中特别丰富。
It is becoming increasingly clear that most of the intracellular compartments that contain MHC class II products in antigen-presenting cells simply represent the conventional endosomes and lysosomes that are expressed in all cell types. Data from recent cell fractionation studies, however, predominantly those using electrophoresis techniques, show that a population of class-II-containing vesicles exists that may comprise a class of endosomes that are specialized for antigen processing. Strong support for this possibility comes from the observation that such specialized structures, designated class II vesicles (CIIV), are particularly abundant in mature dendritic cells.