Natural History of Persistently Elevated Prostate Specific Antigen After Radical Prostatectomy: Results From the SEARCH Database
Natural History of Persistently Elevated Prostate Specific Antigen After Radical Prostatectomy: Results From the SEARCH Database
复制标题
DOI：
10.1016/j.juro.2009.07.022
复制
发表时间：
2009-11-01
影响因子：
6.6
通讯作者：
Freedland, Stephen J.
中科院分区：
文献类型：
--
作者：
Moreira, Daniel M.;Presti, Joseph C., Jr.;Freedland, Stephen J.
目的：我们在共享平等访问区域癌症医院队列中检查了根治性前列腺切除术后前列腺特异性抗原持续升高的患者的自然史、生化复发预测因素和全因死亡率。材料和方法：我们回顾了 1997 年之后接受根治性前列腺切除术治疗的 1,156 名男性的数据。前列腺特异性抗原持续性定义为术后 6 个月内未能达到低于 0.03 ng/ml 的前列腺特异性抗原。使用对数秩检验比较具有和不具有持久性的男性之间的无病生存率和总生存率。使用 Cox 模型分析生化复发和全因死亡的预测因子。 结果：共有 291 名男性 (25%) 具有持久性，这与生化复发和全因死亡增加相关 (p
Purpose: We examined natural history, predictors of biochemical recurrence and all cause mortality in patients with persistently elevated prostate specific antigen after radical prostatectomy in the Shared Equal Access Regional Cancer Hospital cohort.Materials and Methods: We reviewed data on 1,156 men treated with radical prostatectomy after 1997. Prostate specific antigen persistence was defined as failure to achieve prostate specific antigen less than 0.03 ng/ml within 6 months postoperatively. Disease-free and overall survival was compared between men with and without persistence using the log rank test. Predictors of biochemical recurrence and all cause death were analyzed using the Cox model.Results: A total of 291 men (25%) had persistence, which was associated with increased biochemical recurrence and all cause death (p