Viral quasi-species and recombination
Viral quasi-species and recombination
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DOI：
10.1098/rspb.1996.0231
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发表时间：
1996-11-22
影响因子：
4.7
通讯作者：
Nowak, MA
中科院分区：
文献类型：
--
作者：
Boerlijst, MC;Bonhoeffer, S;Nowak, MA
病毒种群是不同但相关的基因组的复杂集合（所谓的准种）。病毒准种的数学描述集中在点突变作为变异的主要来源。然而，逆转录病毒（和许多其他病毒）能够重组它们的基因组。我们研究了一个包含点突变和重组的病毒准种动力学的数学模型。我们发现，低突变率重组可以减少准种的多样性，提高整体健身。然而，对于高突变率，重组可能会将准物种推到错误阈值之上，从而导致所有遗传信息的丢失。最后，重组将双稳性引入准种;如果有利突变体的频率低于一定阈值，它将不会被选择。
Virus populations are complex ensembles of distinct but related genomes (so called quasi-species). Mathematical descriptions of viral quasi-species focus on point mutations as the principal source of variation. However, retroviruses (and many other viruses) are able to recombine their genomes. We study a mathematical model of viral quasi-species dynamics which incorporates both point mutation and recombination. We show that for low mutation rates recombination can reduce the diversity of the quasispecies and enhance overall fitness. For high mutation rates, however, recombination can push the quasi-species over the error threshold, and thereby cause a loss of all genetic information. Finally, recombination introduces bistability to the quasi-species; if the frequency of an advantageous mutant is below a certain threshold, it will not be selected.