Sleep Deprivation, a Link Between Post-Traumatic Stress Disorder and Alzheimer's Disease.
Sleep Deprivation, a Link Between Post-Traumatic Stress Disorder and Alzheimer's Disease.
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DOI：
10.3233/jad-201378
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Citron BA
中科院分区：
文献类型：
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作者：
Delic V;Ratliff WA;Citron BA
据估计，有500万美国人患有阿尔茨海默病(AD)，这对照顾者也有重大影响，另外还有1600万美国人为患有AD和其他痴呆症的个人提供无偿护理。这些数字预计在未来几年还会增加。虽然阿尔茨海默病仍然没有治愈的方法，但持续的研究努力已经使人们更好地了解了病理和潜在的风险因素，这些因素可以用来减缓疾病的进展。睡眠剥夺与阿尔茨海默病之间存在双向关系，人类和动物研究都很好地支持了这一点。即使是短暂的睡眠不足也会导致淀粉样蛋白β和tau蛋白的增加，这两种蛋白都是AD病理的公认贡献者。睡眠不足也是创伤后应激障碍(PTSD)最常见的后果。患有创伤后应激障碍的患者经常出现睡眠障碍，而且患痴呆症的比例是普通人群的两倍，这在美国退伍军人中占AD的比例不成比例。本综述的目的是强调睡眠剥夺、阿尔茨海默病和创伤后应激障碍三者之间的关系，以及它们对推动AD病理的分子机制的影响。
An estimated 5 million Americans are living with Alzheimer’s disease (AD), and there is also a significant impact on caregivers, with an additional 16 million Americans providing unpaid care for individuals with AD and other dementias. These numbers are projected to increase in the coming years. While AD is still without a cure, continued research efforts have led to better understanding of pathology and potential risk factors that could be exploited to slow disease progression. A bidirectional relationship between sleep deprivation and AD has been suggested and is well supported by both human and animal studies. Even brief episodes of inadequate sleep have been shown to cause an increase in amyloid-β and tau proteins, both well-established contributors to AD pathology. Sleep deprivation is also the most common consequence of post-traumatic stress disorder (PTSD). Patients with PTSD frequently present with sleep disturbances and also develop dementia at twice the rate of the general population accounting for a disproportionate representation of AD among U.S. Veterans. The goal of this review is to highlight the relationship triad between sleep deprivation, AD, and PTSD as well as their impact on molecular mechanisms driving AD pathology.