Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy.
Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy.
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抗阻运动训练可降低接受抗病毒治疗的艾滋病毒感染男性的高甘油三酯血症。
DOI：
10.1152/jappl.2001.90.1.133
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Powderly,WG
中科院分区：
文献类型：
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作者：
Yarasheski,KE;Tebas,P;Stanerson,B;Claxton,S;Marin,D;Bae,K;Kennedy,M;Tantisiriwat,W;Powderly,WG
高脂血症、外周胰岛素抵抗和躯干肥胖是最近在感染人类免疫缺陷病毒（HIV）并接受高效抗逆转录病毒治疗（HAART）的人群中发现的代谢并发症。这些并发症可能对运动训练有积极的反应。采用配对设计，我们确定是否16周的举重运动增加肌肉质量和力量，降低空腹血清甘油三酯和脂肪组织质量在18名HIV感染的男性。抗阻运动方案包括3个上半身和4个下半身运动，每天1-1.5小时，每周4天，共64次。双能X线骨密度仪显示，运动训练增加全身瘦体重1.4公斤（P= 0.005），但没有减少脂肪组织质量（P= NS）。轴位质子磁共振成像显示大腿肌肉横截面积增加5-7 cm 2（P< 0.005）。在所有运动中，肌肉力量增加了23-38%（P< 0.0001）。空腹血清甘油三酯在训练结束时降低（281-204 mg/dl;P= 0.02）。这些研究结果表明，抗阻运动训练诱导的肌肉肥大可能会促进高甘油三酯血症的HIV感染者接受抗病毒治疗的循环中甘油三酯的清除。
Hypertriglyceridemia, peripheral insulin resistance, and trunk adiposity are metabolic complications recently recognized in people infected with human immunodeficiency virus (HIV) and treated with highly active antiretroviral therapy (HAART). These complications may respond favorably to exercise training. Using a paired design, we determined whether 16 wk of weight-lifting exercise increased muscle mass and strength and decreased fasting serum triglycerides and adipose tissue mass in 18 HIV-infected men. The resistance exercise regimen consisted of three upper and four lower body exercises done for 1–1.5 h/day, 4 days/wk for 64 sessions. Dual-energy X-ray absorptiometry indicated that exercise training increased whole body lean mass 1.4 kg (P= 0.005) but did not reduce adipose tissue mass (P= NS). Axial proton-magnetic resonance imaging indicated that thigh muscle cross-sectional area increased 5–7 cm2(P< 0.005). Muscle strength increased 23–38% (P< 0.0001) on all exercises. Fasting serum triglycerides were decreased at the end of training (281–204 mg/dl;P= 0.02). These findings imply that resistance exercise training-induced muscle hypertrophy may promote triglyceride clearance from the circulation of hypertriglyceridemic HIV-infected men treated with antiviral therapy.