Penetration of moxifloxacin into bone in patients undergoing total knee arthroplasty
Penetration of moxifloxacin into bone in patients undergoing total knee arthroplasty
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DOI：
10.1093/jac/dkl091
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发表时间：
2006-05-01
影响因子：
5.2
通讯作者：
Baldelli, F
中科院分区：
文献类型：
--
作者：
Malincarne, L;Ghebregzabher, M;Baldelli, F
目的：为了研究血浆和骨中的氟诺沙星浓度口服单剂量或双剂量的药物后，为了考虑其潜在的作用，在治疗骨髓炎。患者和方法：30例接受全膝关节置换术的患者被招募。分为3组，每组10例患者：A组术前2 h（范围1.5-2.5）口服利福沙星400 mg，B组术前4 h（范围3.5-4.5）口服利福沙星400 mg，C组术前14 h口服利福沙星400 mg，然后在术前2 h（范围1.5-2.5）第二次给药。结果：A组血浆、松质骨和皮质骨的平均浓度分别为3.45、1.89和1.43 mg/L，B组分别为3.73、1.81和1.56 mg/L，B组分别为3.45、1.89和1.43 mg/L。C组分别为6.26、2.97和2.54 mg/L。结论：盐酸氟沙星对松质骨和皮质骨均有良好的渗透性，双倍剂量后，其浓度超过了对大多数骨髓炎致病菌的MIC 90和对结核分枝杆菌的临床敏感性折点。
Objectives: To investigate plasma and bone moxifloxacin concentrations following oral administration of a single or double dose of the drug, in order to consider its potential role in the treatment of osteomyelitis.Patients and methods: Thirty consecutive patients undergoing total knee arthroplasty were recruited. Three groups, of ten patients each, were formed: group A received moxifloxacin 400 mg orally 2 h (range 1.5-2.5) preoperatively, group B received moxifloxacin 400 mg orally 4 h (range 3.5-4.5) preoperatively and group C received moxifloxacin 400 mg orally 14 h preoperatively, followed by a second dose 2 h (range 1.5-2.5) preoperatively. During surgery, at the time of bone removal, a blood sample and aliquots of cortical and cancellous bone were collected and moxifloxacin concentrations were measured by HPLC.Results: Mean plasma, cancellous bone and cortical bone concentrations were, respectively: 3.45, 1.89 and 1.43 mg/L for group A; 3.73, 1.81 and 1.56 mg/L for group B; and 6.26, 2.97 and 2.54 mg/L for group C.Conclusions: These data show a good penetration of moxifloxacin into both cancellous and cortical bone, with concentrations, after double dosing, exceeding the MIC90 for most pathogens involved in osteomyelitis and the clinic susceptibility breakpoint for Mycobacterium tuberculosis.