Changes in neuropsychological functioning with progression of HIV-1 infection: Results of an 8-year longitudinal investigation
Changes in neuropsychological functioning with progression of HIV-1 infection: Results of an 8-year longitudinal investigation
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DOI：
10.1023/b:aibe.0000044081.42034.54
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发表时间：
2004-09-01
影响因子：
4.4
通讯作者：
Evans, DL
中科院分区：
文献类型：
--
作者：
Baldewicz, TT;Leserman, J;Evans, DL
尽管出现了更有效的治疗HIV-1感染的方法，但认知障碍仍然很常见，关于在不同的疾病阶段哪些领域的障碍更常见的问题仍然存在。本研究调查了59名HIV-1血清阳性（HIV-1（+））男性在8年的时间内的认知表现，这些男性在研究入组时无临床症状，并与55名HIV-1血清阴性（HIV-1（-））男性进行了比较。每6个月，我们检查5个领域的认知功能-精细运动速度，注意力，言语记忆，执行功能和信息处理速度。我们发现，艾滋病患者的精细运动速度和信息处理速度明显低于HIV-1（-）个体和HIV-1（+）非艾滋病患者。此外，HIV-1（+）非艾滋病患者比HIV-1（-）组在信息处理速度方面表现更差。抑郁症状还与注意力、执行功能和信息处理速度等指标的表现下降有关。需要进一步研究，以检查疾病阶段和抑郁症对新的艾滋病毒治疗时代认知障碍的影响。
Despite the advent of more effective treatments for HIV-1 infection, cognitive impairment is still frequent and questions remain regarding which areas of impairment are more common in the different disease stages. This study investigated cognitive performance over an 8-year period of time in 59 HIV-1 seropositive ( HIV-1(+)) men who were clinically asymptomatic at study entry, in comparison to a cohort of 55 HIV-1 seronegative ( HIV-1(-)) men. Every 6 months we examined cognitive functioning in 5 domains-fine motor speed, attention, verbal memory, executive functioning, and speed of information processing. We found that patients with AIDS scored significantly worse on fine motor speed and speed of information processing than HIV-1(-) individuals and the HIV-1(+) non-AIDS patients. In addition, the HIV-1(+) non-AIDS patients performed more poorly than the HIV-1(-) group on speed of information processing. Depressive symptoms were also associated with diminished performance on measures of attention, executive functioning, and speed of information processing. Further research is needed to examine the effects of disease stage and depression on cognitive impairment in the era of new HIV treatments.