Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study
Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study
复制标题
DOI：
10.1152/ajpendo.00143.2006
复制
发表时间：
2006-12-01
影响因子：
5.1
通讯作者：
Madsen, Klavs
中科院分区：
文献类型：
--
作者：
Kvorning, Thue;Andersen, Marianne;Madsen, Klavs
我们假设内源性睾酮的抑制会抑制健康男性对力量训练的适应。22名缺乏力量训练经验的年轻男性参加了这项随机、安慰剂对照、双盲干预研究。受试者随机接受GnRH类似物goserelin （3.6 mg）或安慰剂（生理盐水）治疗，每4周皮下注射一次，持续12周。力量训练为期8周，从第4周开始，包括所有主要肌肉的锻炼[每次锻炼3-4组x 6-10次重复，相应的6-10次最大（RM）负荷，3次/周]。在第4周和第12周进行力量测试、血液采样和全身DEXA扫描。戈舍林组内源性睾酮从22.6 +/- 5.5（平均+/- SD） nmol/l显著下降（P < 0.01）至2.0 +/- 0.5（第4周）和1.1 +/- 0.6 nmol/l（第12周），而安慰剂组保持不变。戈舍瑞林组训练后膝关节伸展强度无变化，而安慰剂组从240.2 +/- 41.3 Nm增加到264.1 +/- 35.3 Nm（组内P < 0.05，组间P = 0.05）。戈舍瑞林组和安慰剂组腿瘦质量分别增加0.37 +/- 0.13和0.57 +/- 0.30 kg（组内P < 0.05，组间P = 0.05）。戈舍瑞林组和安慰剂组体脂质量分别增加1.4 +/- 1.0 kg和减少0.6 +/- 1.2 kg（组内组间P < 0.05）。我们得出结论，内源性睾酮对力量训练的适应至关重要。
We hypothesized that suppression of endogenous testosterone would inhibit the adaptations to strength training in otherwise healthy men. Twenty-two young men with minor experience with strength training participated in this randomized, placebo-controlled, double-blinded intervention study. The subjects were randomized to treatment with the GnRH analog goserelin (3.6 mg) or placebo (saline) subcutaneously every 4 wk for 12 wk. The strength training period of 8 wk, starting at week 4, included exercises for all major muscles [3-4 sets per exercise x 6-10 repetitions with corresponding 6- to 10-repetition maximum (RM) loads, 3/wk]. A strength test, blood sampling, and whole body DEXA scan were performed at weeks 4 and 12. Endogenous testosterone decreased significantly (P < 0.01) in the goserelin group from 22.6 +/- 5.5 (mean +/- SD) nmol/l to 2.0 +/- 0.5 (week 4) and 1.1 +/- 0.6 nmol/l (week 12), whereas it remained constant in the placebo group. The goserelin group showed no changes in isometric knee extension strength after training, whereas the placebo group increased from 240.2 +/- 41.3 to 264.1 +/- 35.3 Nm (P < 0.05 within and P = 0.05 between groups). Lean mass of the legs increased 0.37 +/- 0.13 and 0.57 +/- 0.30 kg in the goserelin and placebo groups, respectively (P < 0.05 within and P = 0.05 between groups). Body fat mass increased 1.4 +/- 1.0 kg and decreased 0.6 +/- 1.2 kg in the goserelin and placebo groups, respectively (P < 0.05 within and between groups). We conclude that endogenous testosterone is of paramount importance to the adaptation to strength training.