Effects of fucoidan from Mozuku on human stomach cell lines
Effects of fucoidan from Mozuku on human stomach cell lines
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DOI：
10.3136/fstr.12.218
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发表时间：
2006-08-01
影响因子：
0.6
通讯作者：
Matsuda, Hideyuki
中科院分区：
文献类型：
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作者：
Kawamoto, Hitoshi;Miki, Yasunari;Matsuda, Hideyuki
冈村枝管藻（Cladosiphon okamuranus，Okinawamozuku）是一种已知含有褐藻中最多岩藻多糖的水藻。褐藻糖胶是一种具有多种生物活性的硫酸酯化杂多糖。从C.冈村。岩藻聚糖硫酸酯的得率为1.0%（w/w）。冈村。岩藻依聚糖硫酸盐含量和分子量分别为9.8%（w/w）和约3，200，000。我们研究了褐藻糖胶对人胃细胞系的影响。褐藻糖胶C. Okamuranus677.st正常胃细胞中显示出对抗癌剂5-氟尿嘧啶（5-FU）的抑制作用，对5-FU在癌细胞中的原始作用的抑制最小。此外，C.冈村藻对胃癌细胞的生长有抑制作用，但对正常细胞没有任何影响。因此，从Mozuku，特别是C。Okamuranus可能对癌症治疗有用。
Cladosiphon okamuranus (Okinawamozuku) is a species of Mozuku known to contain the most fucoidan of any brown algae. Fucoidan is a sulfated hetero polysaccharide with various biological activities. We isolated and purified fucoidan from C. okamuranus. The yield of fucoidan was 1.0% (w/w) based on wet algae from C. okamuranus. The sulfate content and molecular weight of the fucoidan were 9.8% (w/w) and approximately 3,200,000, respectively. We examined the effects of fucoidan on human stomach cell lines. Fucoidan from C. okamuranus showed an inhibitory effect on anticancer agent 5-fluorouracil (5-FU) in Hs 677.st normal stomach cells with minimum inhibition of the original effect of 5-FU in cancer cells. Furthermore, fucoidan from C. okamuranus showed growth inhibition of stomach cancer cells but did not show any effects on normal cells. Thus, fucoidan from Mozuku, especially C. okamuranus, may be useful for cancer therapy.