Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory
Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory
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DOI：
10.1111/jsr.12001
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发表时间：
2013-04-01
影响因子：
4.4
通讯作者：
Dijk, Derk-Jan
中科院分区：
文献类型：
--
作者：
Lazar, Alpar S.;Santhi, Nayantara;Dijk, Derk-Jan
睡眠抱怨和不规律的睡眠模式很常见，例如工作日睡眠时间减少以及周末睡眠时间延长和推迟。通常暗示昼夜节律周期和夹带阶段的差异导致了这些模式，但可用的数据很少。我们评估了 35 名没有睡眠障碍的参与者（18 名女性）在基线和强制去同步方案中的褪黑激素昼夜节律参数。昼夜节律在23小时50分钟和24小时31分钟之间变化，并且与相对于习惯就寝时间的褪黑激素节律时间呈正相关（n=31，rs=0.43，P=0.017）。褪黑激素节律的相位与失眠严重指数相关（n=35，rs=0.47，P=0.004）。自由日期间自我报告的卧床时间也与褪黑激素节律的时间相关（n = 35，rs = 0.43，P = 0.01）以及昼夜节律周期（n = 31，rs = 0.47，P = 0.007），因此褪黑激素节律较延迟或昼夜节律较长的个体报告周末睡眠时间较长。空闲日卧床时间的增加与昼夜节律呈正相关（n=31，rs=0.54，P=0.002）。当参与者在实验室按习惯就寝时间睡觉时，多导睡眠图评估的持续睡眠潜伏期（n=34，rs=0.48，P=0.004）与褪黑激素节律的时间相关。这种相关性在女性中明显强于男性（Z=2.38，P=0.017）。研究结果表明，昼夜节律和褪黑激素节律阶段的个体差异与睡眠差异相关，并表明昼夜节律较长的个体可能存在出现睡眠问题的风险。
Sleep complaints and irregular sleep patterns, such as curtailed sleep during workdays and longer and later sleep during weekends, are common. It is often implied that differences in circadian period and in entrained phase contribute to these patterns, but few data are available. We assessed parameters of the circadian rhythm of melatonin at baseline and in a forced desynchrony protocol in 35 participants (18 women) with no sleep disorders. Circadian period varied between 23h 50min and 24h 31min, and correlated positively (n=31, rs=0.43, P=0.017) with the timing of the melatonin rhythm relative to habitual bedtime. The phase of the melatonin rhythm correlated with the Insomnia Severity Index (n=35, rs=0.47, P=0.004). Self-reported time in bed during free days also correlated with the timing of the melatonin rhythm (n=35, rs=0.43, P=0.01) as well as with the circadian period (n=31, rs=0.47, P=0.007), such that individuals with a more delayed melatonin rhythm or a longer circadian period reported longer sleep during the weekend. The increase in time in bed during the free days correlated positively with circadian period (n=31, rs=0.54, P=0.002). Polysomnographically assessed latency to persistent sleep (n=34, rs=0.48, P=0.004) correlated with the timing of the melatonin rhythm when participants were sleeping at their habitual bedtimes in the laboratory. This correlation was significantly stronger in women than in men (Z=2.38, P=0.017). The findings show that individual differences in circadian period and phase of the melatonin rhythm associate with differences in sleep, and suggest that individuals with a long circadian period may be at risk of developing sleep problems.