A fishy tail: Insights into the cell and molecular biology of neuromesodermal cells from zebrafish embryos.
A fishy tail: Insights into the cell and molecular biology of neuromesodermal cells from zebrafish embryos.
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鱼尾：深入了解斑马鱼胚胎神经中胚层细胞的细胞和分子生物学。
DOI：
10.1016/j.ydbio.2022.04.010
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发表时间：
2022
影响因子：
2.7
通讯作者：
Steventon,Benjamin
中科院分区：
文献类型：
--
作者：
Martin,BenjaminL;Steventon,Benjamin
脊椎动物胚胎以一种保守的循序渐进的方式从前面到后面建立了他们的初级体轴。在这一过程中，随着胚胎的伸长，被称为神经中胚层前体细胞的神经中胚层细胞群在向脊髓和中胚层提供新细胞方面发挥了关键作用。神经中胚层群体发育的缺陷可能导致头部后方身体形成的严重中断。鉴于它们在发育过程中的重要性和它们的潜力(其中一些已经被实现)，对于揭示体外组织生成的新方法，人们对更好地理解NMP生物学非常感兴趣。斑马鱼模型系统有助于促进我们对纳米细胞群体及其衍生物的分子和细胞属性的理解。在这篇综述中，我们着重于我们对斑马鱼NM种群及其对体轴形成的贡献的了解，特别是对促进或抑制分化的谱系潜力、形态发生和生态位因素的认识。
Vertebrate embryos establish their primary body axis in a conserved progressive fashion from the anterior to the posterior. During this process, a posteriorly localized neuromesodermal cell population called neuromesodermal progenitors (NMps) plays a critical role in contributing new cells to the spinal cord and mesoderm as the embryo elongates. Defects in neuromesodermal population development can cause severe disruptions to the formation of the body posterior to the head. Given their importance during development and their potential, some of which has already been realized, for revealing new methods of in vitro tissue generation, there is great interest in better understanding NMp biology. The zebrafish model system has been instrumental in advancing our understanding of the molecular and cellular attributes of the NM cell population and its derivatives. In this review, we focus on our current understanding of the zebrafish NM population and its contribution to body axis formation, with particular emphasis on the lineage potency, morphogenesis, and niche factors that promote or inhibit differentiation.