Following Cancer Prevention Guidelines Reduces Risk of Cancer, Cardiovascular Disease, and All-Cause Mortality
Following Cancer Prevention Guidelines Reduces Risk of Cancer, Cardiovascular Disease, and All-Cause Mortality
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DOI：
10.1158/1055-9965.epi-10-1173
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发表时间：
2011-06-01
影响因子：
3.8
通讯作者：
Gapstur, Susan M.
中科院分区：
文献类型：
--
作者：
McCullough, Marjorie L.;Patel, Alpa V.;Gapstur, Susan M.
背景资料：很少有研究评估以下推荐的生活方式行为对癌症，心血管疾病（CVD）和全因死亡率的综合影响，大多数包括避免吸烟。因为80%的美国人从来没有或以前吸烟者，重要的是要考虑其他建议的behaviors.Methods的影响：在1992年和1993年，111,966不吸烟的男性和女性在癌症预防研究-II营养队列完成饮食和生活方式问卷调查。计算范围为0至8分的评分，以反映对美国癌症协会癌症预防指南关于体重指数、身体活动、饮食和饮酒的依从性，其中8分代表最佳依从性。通过考克斯比例风险回归计算死亡的多变量调整相对危险度（RR）和95%CI。结果：在14年的随访中，10，369名男性和6，613名女性死亡。高评分（7，8）与低评分（0-2）参与者的全因死亡率RR较低（男性，RR = 0.58，95% CI：0.53-0.62;女性，RR 0.58，95% CI：0.52-0.64）。发现CVD死亡率（男性，RR = 0.52，95% CI：0.45-0.59;女性，RR = 0.42，95% CI：0.35-0.51）和癌症死亡率（男性，RR = 0.70，95% CI：0.61-0.80;女性，RR = 0.76，95% CI：0.65-0.89）呈负相关。类似的协会，虽然不是所有的统计学显着，观察从未和前smoker.Conclusion：坚持癌症预防指南的肥胖，饮食，体力活动，和酒精消费与癌症，心血管疾病，和所有原因的死亡风险较低nonsmoker.Impact：除了避免吸烟，以下其他癌症预防指南可能会大大降低老年人过早死亡的风险。癌症流行病学生物标志物Prev; 20（6）; 1089-97。（C）2011年《非洲标准化评论》。
Background: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on cancer, cardiovascular disease (CVD) and all-cause mortality, and most included tobacco avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors.Methods: In 1992 and 1993, 111,966 nonsmoking men and women in the Cancer Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American Cancer Society cancer prevention guidelines on body mass index, physical activity, diet, and alcohol consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of death and 95% CI were computed by Cox proportional hazard regression.Results: During 14 years of follow-up, 10,369 men and 6,613 women died. The RR of all-cause mortality was lower for participants with high (7, 8) versus low (0-2) scores (men, RR = 0.58, 95% CI: 0.53-0.62; women, RR 0.58, 95% CI: 0.52-0.64). Inverse associations were found with CVD mortality (men, RR = 0.52, 95% CI: 0.45-0.59; women, RR = 0.42, 95% CI: 0.35-0.51) and cancer mortality (men, RR = 0.70, 95% CI: 0.61-0.80; women, RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers.Conclusion: Adherence to cancer prevention guidelines for obesity, diet, physical activity, and alcohol consumption is associated with lower risk of death from cancer, CVD, and all causes in nonsmokers.Impact: Beyond tobacco avoidance, following other cancer prevention guidelines may substantially lower risk of premature mortality in older adults. Cancer Epidemiol Biomarkers Prev; 20(6); 1089-97. (C)2011 AACR.