CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation
CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation
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DOI：
10.1182/blood-2005-11-007237
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发表时间：
2006-11-01
期刊：
影响因子：
20.3
通讯作者：
van der Bruggen, Pierre
中科院分区：
文献类型：
--
作者：
Carrasco, Javier;Godelaine, Daniele;van der Bruggen, Pierre
CCR 7（-）人CD 8（+）记忆T细胞上CD 45 RA的表达被广泛认为是终末分化的标志物。我们研究了抗原刺激后，人抗肿瘤细胞毒性T淋巴细胞（CTL）克隆和血液CD 8（+）T细胞上CD 45 RA和CCR 7表达的时程。我们的研究结果表明，CD 45 RA（+）CCR 7（-）CD 8（+）T细胞是静息记忆细胞，在抗原刺激后，在接下来的10天内，增殖，失去CD 45 RA，并短暂获得CCR 7。在没有进一步抗原刺激的情况下，它们逐渐重新表达CD 45 RA并变成CD 45 RA（+）CCR 7（-）。我们的结论是，这些细胞上的CD 45 RA的表达是指示的时间流逝，因为最后的抗原刺激，而不是不能增殖或特别高的裂解潜力。这一概念导致重新解释了在受病毒感染或癌症影响的患者中存在CD 45 RA（+）CD 8（+）记忆细胞的意义。
The expression of CD45RA on CCR7(-) human CD8(+) memory T cells is widely considered to be a marker of terminal differentiation. We studied the time course of CD45RA and CCR7 expression on human antitumoral cytotoxic T lymphocyte (CTL) clones and blood CD8(+) T cells after antigenic stimulation. Our results indicate that CD45RA(+)CCR7(-) CD8(+) T cells are resting memory cells that, upon anti-genic stimulation and during the next 10 days, proliferate, lose CD45RA, and transiently acquire CCR7. In the absence of further antigenic stimulation, they progressively re-express CD45RA and become CD45RA(+)CCR7(-). We conclude that the expression of CD45RA on these cells is indicative of the time elapsed since the last antigenic stimulation rather than the incapacity to proliferate or particularly high lytic potential. This concept leads to a reinterpretation of the significance of the presence of CD45RA(+) CD8(+) memory cells in patients affected by viral infections or by cancer.