AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression.
AEG-1/MTDH/LYRIC, the beginning: initial cloning, structure, expression profile, and regulation of expression.
复制标题
DOI：
10.1016/b978-0-12-401676-7.00001-2
复制
发表时间：
2013
影响因子：
--
通讯作者：
Fisher, Paul B.
中科院分区：
文献类型：
--
作者：
Lee, Seok-Geun;Kang, Dong-Chul;DeSalle, Rob;Sarkar, Devanand;Fisher, Paul B.
自2002年首次鉴定为HIV-1诱导基因以来，星形胶质细胞升高基因-1（AEG-1），随后克隆为metadherin（MTDH）和富含赖氨酸的CEACAM 1共分离（LYRIC），在过去10年中已成为一种重要的癌基因，为各种癌症患者提供了有价值的预后标志物。最近的研究表明，AEG-1/MTDH/LYRIC是一种多效性蛋白，可定位于细胞膜、细胞质、内质网（ER）、细胞核和核仁中，参与多种信号通路如PI 3 K-AKT、NF-κB、MAPK和Wnt。除了肿瘤发生之外，这种多功能蛋白质还涉及各种生理和病理过程，包括发育、神经变性和炎症。本综述的重点是AEG-1/MTDH/LYRIC的发现和概念化的未来方向，这个有趣的基因的领域。我们开始描述如何AEG-1，MTDH和LYRIC最初确定的不同的研究小组，然后讨论AEG-1的结构，功能，定位和进化。最后，我们讨论了AEG-1/MTDH/LYRIC在癌症、神经系统疾病、炎症和胚胎发生中的表达谱，并讨论了AEG-1/MTDH/LYRIC是如何被调节的。AEG-1/MTDH/LYRIC的介绍性讨论将作为其他章节详细讨论这种有趣分子独特性质的基础。
Since its initial identification as a HIV-1-inducible gene in 2002, astrocyte elevated gene-1 (AEG-1), subsequently cloned as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), has emerged over the past 10 years as an important oncogene providing a valuable prognostic marker in patients with various cancers. Recent studies demonstrate that AEG-1/MTDH/LYRIC is a pleiotropic protein that can localize in the cell membrane, cytoplasm, endoplasmic reticulum (ER), nucleus, and nucleolus, and contributes to diverse signaling pathways such as PI3K–AKT, NF-κB, MAPK, and Wnt. In addition to tumorigenesis, this multifunctional protein is implicated in various physiological and pathological processes including development, neurodegeneration, and inflammation. The present review focuses on the discovery of AEG-1/MTDH/LYRIC and conceptualizes areas of future direction for this intriguing gene. We begin by describing how AEG-1, MTDH, and LYRIC were initially identified by different research groups and then discuss AEG-1 structure, functions, localization, and evolution. We conclude with a discussion of the expression profile of AEG-1/MTDH/LYRIC in the context of cancer, neurological disorders, inflammation, and embryogenesis, and discuss how AEG-1/MTDH/LYRIC is regulated. This introductory discussion of AEG-1/MTDH/LYRIC will serve as the basis for the detailed discussions in other chapters of the unique properties of this intriguing molecule.