fMRI study of language lateralization in children and adults
fMRI study of language lateralization in children and adults
复制标题
DOI：
10.1002/hbm.20177
复制
发表时间：
2006-03-01
影响因子：
4.8
通讯作者：
Byars, AW
中科院分区：
文献类型：
--
作者：
Szaflarski, JP;Holland, SK;Byars, AW
语言在大脑中的偏侧化取决于家族利手史、个人利手、病理学和其他因素。年龄对语言偏侧化的影响尚未完全清楚。在儿童中观察到随着年龄的增长，语言的左侧化增加，而在健康的年轻人中则相反。目前尚不清楚语言偏侧化随着年龄的增长而减少的趋势是否会在生命的最后几十年继续下去，以及语言偏侧化趋势作为年龄的函数在什么年龄发生拐点。在这项研究中，我们研究了年龄对语言偏侧化的影响，在170名健康的右利手儿童和成人年龄5-67使用功能磁共振成像（fMRI）和动词生成任务。我们的研究结果表明，语言偏侧化的优势半球之间的年龄增加5和20岁，高原之间的20和25岁，并缓慢下降之间的25和70岁。
Language lateralization in the brain is dependent on family history of handedness, personal handedness, pathology, and other factors. The influence of age on language lateralization is not completely understood. Increasing left lateralization of language with age has been observed in children, while the reverse has been noted in healthy young adults. It is not known whether the trend of decreasing language lateralization with age continues in the late decades of life and at what age the inflection in language lateralization trend as a function of age occurs. In this study, we examined the effect of age on language lateralization in 170 healthy right-handed children and adults ages 5-67 using functional MRI (fMRI) and a verb generation task. Our findings indicate that language lateralization to the dominant hemisphere increases between the ages 5 and 20 years, plateaus between 20 and 25 years, and slowly decreases between 25 and 70 years.