Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs
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DOI：
10.1021/ja042967z
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发表时间：
2005-03-23
影响因子：
15
通讯作者：
Nagano, T
中科院分区：
文献类型：
--
作者：
Sasaki, E;Kojima, H;Nagano, T
新型近红外 (NIR) 一氧化氮 (NO) 荧光探针已被设计、合成和评估。在生理条件下，它们的近红外荧光以NO浓度依赖性方式增加，并且它们与NO的反应效率比广泛使用的NO探针DAF-2至少高53倍。它们被证实在分离的完整大鼠肾脏中发挥作用。由于近红外光可以深入组织，这些探针可能具有体内 NO 成像的潜力。
Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.