Maternal and infant urinary phthalate metabolite concentrations: Are they related?
Maternal and infant urinary phthalate metabolite concentrations: Are they related?
复制标题
DOI：
10.1016/j.envres.2008.07.002
复制
发表时间：
2008-11-01
影响因子：
8.3
通讯作者：
Swan, S. H.
中科院分区：
文献类型：
--
作者：
Sathyanarayana, S.;Calafat, A. M.;Swan, S. H.
背景：邻苯二甲酸盐是我们社会中普遍存在的合成化学品，可能对人类健康产生不利影响。在成人和儿童中都发现了可检测到的邻苯二甲酸酯代谢物浓度，但没有研究检验母亲和婴儿邻苯二甲酸酯代谢物浓度之间的关系。目的：我们调查了母亲和婴儿尿液中邻苯二甲酸酯代谢物浓度之间的关系。方法：我们测量了同一研究访视日收集的 210 对母婴尿液样本中的 9 种邻苯二甲酸酯代谢物。 （1999-2005）并通过问卷调查获得人口统计历史。使用多元线性回归分析，我们检查了母亲尿液邻苯二甲酸酯代谢物浓度预测婴儿邻苯二甲酸酯代谢物浓度的程度。所有分析均根据婴儿年龄、肌酐浓度和种族进行调整。结果：母亲与其婴儿尿液中邻苯二甲酸酯代谢物浓度之间的相关系数一般较低，但随着婴儿年龄的降低而增加。在多变量分析中，母亲的邻苯二甲酸酯代谢物浓度与婴儿的六种邻苯二甲酸酯代谢物浓度显着相关：邻苯二甲酸单苄酯、邻苯二甲酸单乙酯、邻苯二甲酸单异丁酯和邻苯二甲酸二（2-乙基己基）酯的三种代谢物：邻苯二甲酸单（2-乙基己基）酯、 邻苯二甲酸单（2-乙基-5-羟基己基）酯和邻苯二甲酸单（2-乙基-5-氧代-己基）酯（所有系数的 p 值 < 0.05）。讨论：对于六种邻苯二甲酸酯代谢物，母亲尿液邻苯二甲酸酯代谢物浓度与婴儿尿液邻苯二甲酸酯代谢物浓度显着相关。在周围环境中共同接触邻苯二甲酸盐似乎是造成这些关系的原因，但其他不明来源也可能导致婴儿接触邻苯二甲酸盐。这项研究表明，为了减少婴儿邻苯二甲酸盐的总体暴露，必须进一步确定婴儿邻苯二甲酸盐的暴露量（可能与母体的暴露量不同）。 (C) 2008 Elsevier Inc. 保留所有权利。
Background: Phthalates are synthetic chemicals that are ubiquitous in our society and may have adverse health effects in humans. Detectable concentrations of phthalate metabolites have been found in adults and children, but no studies have examined the relationship between maternal and infant phthalate metabolite concentrations.Objective: We investigated the relationship between maternal and infant urinary phthalate metabolite concentrations.Methods: We measured nine phthalate metabolites in urine samples from 210 mother/infant pairs collected on the same study visit day (1999-2005) and obtained demographic history from questionnaires. Using multivariate linear regression analyses, we examined the degree to which maternal urine phthalate metabolite concentration predicted infant phthalate metabolite concentration. All analyses were adjusted for infant age, creatinine concentration, and race.Results: Correlation coefficients between phthalate metabolite concentrations in the urine of mothers and their infants were generally low but increased with decreasing age of infant. In multivariate analyses, mother's phthalate metabolite concentrations were significantly associated with infants' concentrations for six phthalate metabolites: monobenzyl phthalate, monoethyl phthalate, monoisobutyl phthalate, and three metabolites of di(2-ethylhexyl) phthalate: mono(2-ethyl hexyl) phthalate, mono(2-ethyl-5-hydroxy-hexyl) phthalate, and mono(2-ethyl-5-oxo-hexyl) phthalate (p-values for all coefficients < 0.05).Discussion: Mother's urine phthalate metabolite concentration is significantly associated with infant urine phthalate metabolite concentration for six phthalate metabolites. It is plausible that shared exposures to phthalates in the immediate surrounding environment accounted for these relationships, but other unidentified sources may also contribute to infants' phthalate exposures. This study indicates the importance of further identifying infant phthalate exposures that may be distinct from maternal exposures in order to decrease overall infant phthalate exposures. (C) 2008 Elsevier Inc. All rights reserved.