Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
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DOI：
10.1021/acsbiomaterials.0c00713
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发表时间：
2020-10-01
影响因子：
5.8
通讯作者：
Braunschweig, Adam B.
中科院分区：
文献类型：
--
作者：
Cerullo, Antonio R.;Lai, Tsoi Ying;Braunschweig, Adam B.
动物分泌粘液的功能非常多样，包括润滑剂、湿粘合剂、保护屏障和矿化剂。尽管黏液存在于所有动物中，但仍存在许多与黏液的等级结构、材料特性和遗传学有关的悬而未决的问题。在这里，我们总结了关于分泌粘液结构的已知内容，描述了世界各地正在研究各种动物粘液的研究小组的工作，并介绍了这些研究如何揭示新的粘液特性以及粘液分层结构与水凝胶功能之间的关系。最后，我们呼吁采用一种更系统的方法来研究动物黏液，以便能够以组学的方式比较数据集，以解决新兴的黏液学领域中尚未解决的问题。我们从这些努力中期待的一个主要结果是设计规则，创造受动物粘液结构和功能启发的新材料。
The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the hierarchical architectures, material properties, and genetics of mucus remain. Here, we summarize what is known about secreted mucus structure, describe the work of research groups throughout the world who are investigating various animal mucuses, and relate how these studies are revealing new mucus properties and the relationships between mucus hierarchical structure and hydrogel function. Finally, we call for a more systematic approach to studying animal mucuses so that data sets can be compared, omics-style, to address unanswered questions in the emerging field of mucomics. One major result that we anticipate from these efforts is design rules for creating new materials that are inspired by the structures and functions of animal mucuses.