CRYSTAL-STRUCTURE OF A Z-DNA FRAGMENT CONTAINING THYMINE 2-AMINOADENINE BASE-PAIRS
CRYSTAL-STRUCTURE OF A Z-DNA FRAGMENT CONTAINING THYMINE 2-AMINOADENINE BASE-PAIRS
复制标题
DOI：
10.1080/07391102.1986.10506337
复制
发表时间：
1986-10-01
影响因子：
4.4
通讯作者：
RICH, A
中科院分区：
文献类型：
--
作者：
COLL, M;WANG, AHJ;RICH, A
Z-DNA结构已被证明是在两个晶体中形成的，这两个晶体由含有胸腺嘧啶/2-氨基腺嘌呤（TD）碱基对的自互补DNA六聚体d（CGTDCG）和d（CDCGTG）制成。后一种结构已被求解并细化到1.3埃。分辨率，并且与d（CG）3的结构相比，由于TD碱基对的引入，它仅显示出小的构象变化。用这些化合物进行的光谱研究表明，含有2-氨基腺嘌呤残基的DNA分子比含有腺嘌呤核苷酸的DNA分子更容易形成Z-DNA，但不像只含有鸟嘌呤-胞嘧啶碱基对的亲本序列那样容易。
The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 .ANG. resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only-guanine-cytosine base pairs.