Age-related variations in corneal biomechanical properties.
Age-related variations in corneal biomechanical properties.
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DOI：
10.1016/j.joco.2016.05.004
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发表时间：
2016-09
影响因子：
1.5
通讯作者：
Cheraghian B
中科院分区：
文献类型：
--
作者：
Sharifipour F;Panahi-Bazaz M;Bidar R;Idani A;Cheraghian B
确定健康个体角膜粘弹性特性的年龄相关变化。本观察性横断面研究在伊朗阿瓦士伊玛目霍梅尼医院眼科进行，纳入了6个年龄段（范围：10-69岁）的302名健康个体。眼部全面检查后，用眼反应分析仪测定角膜粘弹性，用超声测厚仪测定角膜中央厚度。我们的主要结局指标是不同年龄组的角膜粘弹性。角膜迟滞（CH）和角膜阻力因子（CRF）与年龄呈显著负相关（P < 0.001, r = - 0.353和r = - 0.246）。女性患者CH （P = 0.017）和CRF （P = 0.019）显著高于男性。CH与CRF显著相关（P < 0.001, r = 0.821）。CCT表现为双相型，20岁前和50岁后厚度明显增高。CH和CRF与CCT（均P < 0.001, r = 0.21和r = 0.26）和眼压（IOP）（均P < 0.001, r = - 0.474和r = 0.598）显著相关。40岁后角膜代偿IOP （IOPcc）明显高于<20岁组（p < 0.045）。goldmann相关IOP （IOPg）与CCT显著相关（P = 0.001, r = 0.193）， IOPcc与CCT无相关性（P = 0.265, r = 0.062）。远视眼的CH明显高于远视眼（P = 0.009）和近视眼（P < 0.001）。在本研究中，CH和CRF随年龄的增加而下降。远视和女性与较高的CH和CRF有关。CCT在生命极值阶段较高，且与CH和CRF显著相关。
To determine age-related changes in corneal viscoelastic properties in healthy individuals. This observational cross-sectional study was performed at the Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz, Iran and included 302 healthy individuals in 6 age decades (range: 10–69 years). After complete ocular examination, corneal viscoelastic properties were measured by ocular response analyzer and central corneal thickness (CCT) by an ultrasonic pachymeter. Our main outcome measures were corneal viscoelastic properties in different age groups. Corneal hysteresis (CH) and corneal resistance factor (CRF) showed a significant negative correlation with age (P < 0.001 for both, r = −0.353 and r = −0.246, respectively). Female gender had significantly higher CH (P = 0.017) and CRF (P = 0.019). CH and CRF were significantly correlated (P < 0.001, r = 0.821). CCT showed a biphasic pattern with significantly higher thicknesses before 20 and after 50 years of age. CH and CRF were significantly correlated with CCT (P < 0.001 for both, r = 0.21 and r = 0.26, respectively) and intraocular pressure (IOP) (P < 0.001 for both, r = −0.474 and r = 0.598, respectively). Corneal-compensated IOP (IOPcc) was significantly higher after age 40 compared to age group <20 (p < 0.045). Goldmann-correlated IOP (IOPg) was significantly correlated with CCT (P = 0.001, r = 0.193), while IOPcc showed no correlation with CCT (P = 0.265, r = 0.062). CH was significantly higher in hyperopic eyes compared to emmetropic eyes (P = 0.009) and myopic eye (P < 0.001). In this study, there was a decrease in CH and CRF with an increase in age. Hyperopia and female gender are associated with higher CH and CRF. CCT is higher toward the extremes of life and is significantly correlated with CH and CRF.