Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer
Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer
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DOI：
10.1007/s11010-014-2138-8
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发表时间：
2014-11-01
影响因子：
4.3
通讯作者：
Jeong, Kyu-Shik
中科院分区：
文献类型：
--
作者：
Ki, Mi-Ran;Hwang, Meeyul;Jeong, Kyu-Shik
表达cagA和s1a vacA基因的幽门螺杆菌菌株与胃癌风险增加有关。在这里，我们通过对208例常规胃镜检查和43例胃癌患者的胃活检标本进行免疫组化染色，研究了这些毒力基因的产物与胃癌发生的关系。采用多因素logistic回归分析相关性。胃黏膜中CagA和VacA的表达分别与慢性胃炎（CG）和肠化生（IM）显著相关，且随慢性胃炎而发生，与年龄无关。50岁以上患者CagA表达与IM伴CG的相关性增高（p < 0.01）， 50岁以下患者VacA表达与CG的相关性增高（p < 0.05）。VacA和CagA与轻度IM发生率相关（分别为p = 0.025和p = 0.076），但与晚期IM无关。43例胃癌患者中，CG和IM组VacA阳性率明显高于癌组（p = 0.042），而癌组CagA阳性率略高于CG和IM组。这些结果表明，CagA和VacA是诱导CG的关键因素，并且随着年龄的增长，img也随之发展。
Helicobacter (H.) pylori strains that express the cagA and s1a vacA genes are associated with an increased risk for gastric cancer. Here, we examined the association between the products of these virulence genes with the development of gastric cancer by immunohistochemical staining of gastric biopsy specimens taken from 208 routine gastroscopies and 43 gastric cancer patients. The correlation was analyzed by multivariate logistic regression. CagA and VacA expressions in gastric mucosa were significantly associated with chronic gastritis (CG) and intestinal metaplasia (IM), respectively, accompanying CG independent of age. The association of CagA expression with IM accompanying CG was increased in patients over 50-year old (p < 0.01) and that of VacA with CG was significant in patients younger than 50 year (p < 0.05). VacA and CagA were associated with mild IM incidence (p = 0.025 and p = 0.076, respectively) but not advanced IM. In the 43 gastric cancer patients, positivity for VacA was significantly higher in cases of CG and IM than carcinoma (p = 0.042), while that for CagA was slightly higher for individuals with carcinoma than those with CG and IM. These results indicate that CagA and VacA are critical factors for inducing CG and the subsequent progression of IM from CG with an increasing age.