Elevated soluble IL-2Rα, IL-8, and MIP-1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma.
Elevated soluble IL-2Rα, IL-8, and MIP-1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma.
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DOI：
10.1002/ajh.23838
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发表时间：
2014-12
影响因子：
12.8
通讯作者：
Gupta, Mamta
中科院分区：
文献类型：
--
作者：
Sonbol, Mohamad B.;Maurer, Matthew J.;Stenson, Mary J.;Allmer, Cristine;LaPlant, Betsy R.;Weiner, George J.;Macon, William R.;Cerhan, James R.;Witzig, Thomas E.;Gupta, Mamta
套细胞淋巴瘤（MCL）是一种独特类型的淋巴瘤，其预后介于惰性和侵袭性类型之间。本研究的目的是研究新诊断和复发的MCL患者的血液细胞因子水平的异常模式和与MCL国际预后指数（MIPI）评分的关系。我们使用多重ELISA分析了88例新诊断的MCL患者（治疗前水平）和20例复发MCL患者的30种细胞因子的血液水平，并将其与无已知淋巴瘤的对照组进行比较。将升高的细胞因子水平与临床结果和MIPI评分进行比较。88例初治MCL患者IL-12、IP-10、sIL-2 R α、IL-1 RA、IL-8、MIP-1α、MIP-1β水平均显著高于对照组（P<0.05）。在这些升高的细胞因子中，sIL-2 R α、IL-8、TNF α、MIP-1α和MIP-1β预测无事件生存率较低，而sIL-2 R α、IL-8、TNF α和MIP-1β预测无事件生存率较低。（HR=1.94; p=0.038），IL-8（HR=2.17; p=0.015）和MIP-1β（HR=2.10; p=0.016）与MIPI评分无关;仅sIL-2 R α（HR=2.35; p=0.041）与MIPI校正后的总生存率相关。在复发性MCL患者组中，预测EFS的血浆细胞因子仅显著升高的是sIL-2 R α（HR=2.90; p=0.04）和IL-8（HR=3.75; p=0.02）。血清sIL-2 R α和促炎细胞因子IL-8和MIP-1β水平升高是MCL患者预后不良的因素，与MIPI评分无关。这些因素如果得到验证，将为MIPI提供重要补充，并指导这些细胞因子水平升高的患者开发新疗法。
Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prognostic Index (MIPI) score. We analyzed blood levels of 30 cytokines using a multiplex ELISA in 88 patients with newly diagnosed MCL (pre-treatment levels) and 20 with relapsed MCL and compared them with controls without known lymphoma. Elevated cytokine levels were compared with clinical outcome and the MIPI score. In the 88 newly diagnosed MCL patients we found significantly elevated levels compared to controls of IL-12, IP-10, sIL-2Rα, MIG, IL-1RA, IL-8, MIP-1α and MIP-1β (all p<0.05). Of these elevated cytokines, sIL-2Rα, IL-8, MIG, MIP-1α and MIP-1β were predictive of inferior event-free survival, and sIL-2Rα (HR=1.94; p=0.038), IL-8 (HR=2.17; p=0.015), and MIP-1β (HR=2.10; p=0.016) were independent of MIPI score; only sIL-2Rα (HR=2.35; p=0.041) was associated with overall survival after adjustment for MIPI. In the relapsed MCL patient group, the only significantly elevated plasma cytokines that predicted EFS were sIL-2Rα (HR=2.90; p=0.04) and IL-8 (HR=3.75; p=0.02). Elevated blood levels of sIL-2Rα and the pro-inflammatory cytokines IL-8 and MIP-1β are poor prognostic factors in MCL patients and independent of MIPI score. These factors, if validated, will provide important additions to the MIPI and guide the development of new therapies for patients with elevated levels of these cytokines.
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影响因子：
6.4
作者：
Lindqvist, Camilla A.;Christiansson, Lisa H.;Loskog, Angelica S. I.
通讯作者：
Loskog, Angelica S. I.
影响因子：
3.8
作者：
Charbonneau, Bridget;Maurer, Matthew J.;Ansell, Stephen M.;Slager, Susan L.;Fredericksen, Zachary S.;Ziesmer, Steven C.;Macon, William R.;Habermann, Thomas M.;Witzig, Thomas E.;Link, Brian K.;Cerhan, James R.;Novak, Anne J.
通讯作者：
Novak, Anne J.
DOI：
10.1056/nejmoa1306220
发表时间：
2013-08-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Wang ML;Rule S;Martin P;Goy A;Auer R;Kahl BS;Jurczak W;Advani RH;Romaguera JE;Williams ME;Barrientos JC;Chmielowska E;Radford J;Stilgenbauer S;Dreyling M;Jedrzejczak WW;Johnson P;Spurgeon SE;Li L;Zhang L;Newberry K;Ou Z;Cheng N;Fang B;McGreivy J;Clow F;Buggy JJ;Chang BY;Beaupre DM;Kunkel LA;Blum KA
通讯作者：
Blum KA
影响因子：
11.5
作者：
Waugh, David J. J.;Wilson, Catherine
通讯作者：
Wilson, Catherine
DOI：
10.1182/asheducation-2011.1.178
发表时间：
2011-12-01
影响因子：
3
作者：
Weitzman, Sheila
通讯作者：
Weitzman, Sheila