CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+ T Cells
CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+ T Cells
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DOI：
10.1074/jbc.m804112200
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发表时间：
2008-11-07
影响因子：
4.8
通讯作者：
Spector, Stephen A.
中科院分区：
文献类型：
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作者：
Campbell, Grant R.;Spector, Stephen A.
在人类免疫缺陷病毒1型（HIV-1）感染期间，CCL 2水平与HIV病毒载量之间存在强正相关性。为了确定CCL 2是否改变HIV-1感染静息CD 4（+）T细胞，我们在与CCL 2孵育后感染纯化的静息CD 4（+）T细胞。我们发现，CCL 2在CCR 2依赖性机制中上调静息CD 4（+）T细胞上的CXCR 4，并且CCL 2对CXCR 4表达的这种增强增加了这些细胞利用gp 120被CXCR 4化学吸引的能力，并使它们对X4-嗜性HIV-1感染更加宽容。因此，CCL 2有能力使大量淋巴细胞在感染过程后期对HIV-1更敏感。
During human immunodeficiency virus type 1 (HIV-1) infection, there is a strong positive correlation between CCL2 levels and HIV viral load. To determine whether CCL2 alters HIV-1 infection of resting CD4(+) T cells, we infected purified resting CD4(+) T cells after incubation with CCL2. We show that CCL2 up-regulates CXCR4 on resting CD4(+) T cells in a CCR2-dependent mechanism, and that this augmentation of CXCR4 expression by CCL2 increases the ability of these cells to be chemoattracted to CXCR4 using gp 120 and renders them more permissive to X4-tropic HIV-1 infection. Thus, CCL2 has the capacity to render a large population of lymphocytes more susceptible to HIV-1 late in the course of infection.