Porphyromonas gingivalis and related bacteria: from colonial pigmentation to the type IX secretion system and gliding motility.
Porphyromonas gingivalis and related bacteria: from colonial pigmentation to the type IX secretion system and gliding motility.
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DOI：
10.1111/jre.12255
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发表时间：
2015-02
影响因子：
3.5
通讯作者：
Nakayama K
中科院分区：
文献类型：
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作者：
Nakayama K
牙龈卟啉单胞菌是一种革兰氏阴性、非运动性、厌氧性细菌，是牙周病的主要病原菌。牙龈假单胞菌在血液琼脂上以黑色素菌落的形式生长，许多细菌学家对这一特性表示出兴趣。对菌落色素沉着的研究揭示了许多重要的发现，包括与牙龈假单胞菌中发现的称为牙龈痛的高度活性的细胞外和表面蛋白水解酶有关。Por分泌系统，一种新的IX型分泌系统(T9SS)，在使用非色素突变体的研究中被认为与牙龈痛的分泌有关。此外，T9SS还可分泌多种强效毒力蛋白，包括金属羧基肽酶CPG70、35 kDa氯化血红素结合蛋白HBP35、肽基精氨酸脱亚胺酶PAD和赖氨酸特异性丝氨酸内肽酶PepK。这些发现并不局限于牙龈假单胞菌，而是扩展到了属于类杆菌门的其他细菌。许多类杆菌都具有T9SS，T9SS与其中一些细菌的滑行运动有关。
Porphyromonas gingivalis is a gram-negative, non-motile, anaerobic bacterium implicated as a major pathogen in periodontal disease. P. gingivalis grows as black-pigmented colonies on blood agar, and many bacteriologists have shown interest in this property. Studies of colonial pigmentation have revealed a number of important findings, including an association with the highly active extracellular and surface proteinases called gingipains that are found in P. gingivalis. The Por secretion system, a novel type IX secretion system (T9SS), has been implicated in gingipain secretion in studies using non-pigmented mutants. In addition, many potent virulence proteins, including the metallocarboxypeptidase CPG70, 35 kDa hemin-binding protein HBP35, peptidylarginine deiminase PAD and Lys-specific serine endopeptidase PepK, are secreted through the T9SS. These findings have not been limited to P. gingivalis but have been extended to other bacteria belonging to the phylum Bacteroidetes. Many Bacteroidetes species possess the T9SS, which is associated with gliding motility for some of these bacteria.