Effects of periodontal therapy on serum lipid profile and proinflammatory cytokines in patients with hyperlipidemia: a randomized controlled trial
Effects of periodontal therapy on serum lipid profile and proinflammatory cytokines in patients with hyperlipidemia: a randomized controlled trial
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DOI：
10.1007/s00784-015-1621-2
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发表时间：
2016-07-01
影响因子：
3.4
通讯作者：
Yang, Yan
中科院分区：
文献类型：
--
作者：
Fu, Yong-Wei;Li, Xiang-Xin;Yang, Yan
本研究的目的是评估牙周炎和高脂血症患者的牙周治疗是否会对血脂和促炎细胞因子水平产生任何影响。我们将109例高脂血症和慢性牙周炎患者随机分为第1组（n = 55）和第2组（n = 54）。第1组患者接受标准周期的龈上机械刮治和抛光。第2组患者接受连续全口强化清除龈下菌斑生物膜，使用洁治和根面平整。周期参数、总胆固醇（TC）、甘油三酯（TRG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1 β在治疗前和治疗后2个月和6个月，2组TRG显著低于1组（P < 0.05），HDL-C显著高于1组（P < 0.05）。治疗后2个月和6个月，第2组的TNF-α水平显著低于第1组（P < 0.05），IL-1 β水平也是如此（P < 0.001）和IL-6高脂血症和慢性牙周炎患者的强化牙周治疗可改善血脂水平，降低循环中的促炎因子，该研究表明，牙周炎的强化治疗导致牙周炎和高脂血症患者的血清脂质水平的改善和血清促炎细胞因子水平的降低。这些发现可能有助于目前的知识，牙周治疗可能是有益的个人与高脂血症。
The aim of this study was to evaluate whether periodontal treatment in patients with periodontitis and hyperlipidemia may have any influence on plasma lipids and pro-inflammatory cytokine levels.We randomly assigned 109 patients with hyperlipidemia and chronic periodontitis into group 1 (n = 55) and group 2 (n = 54). Patients in group 1 underwent a standard cycle of supragingival mechanical scaling and polishing. Patients in group 2 underwent the adjunctive full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planning. Periodontal parameters, total cholesterol (TC), triglyceride (TRG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor-alpha (TNF-alpha), interleukin(IL)-1 beta(IL-1 beta), and IL-6 were evaluated before treatment and 2 and 6 months after treatment.Two and 6 months after treatment, TRG levels were significantly lower in group 2 than in group 1 (P < 0.05), and the levels of HDL-C were significantly higher (P < 0.05). Two and 6 months after therapy, the levels of TNF-alpha were significantly lower in group 2 than in group 1 (P < 0.05), as were the levels of IL-1 beta (P < 0.001) and IL-6 (P < 0.001).Intensive periodontal treatment of participants with hyperlipidemia and chronic periodontitis improved serum lipid levels and decreased circulating pro-inflammatory cytokine levels.This study showed that intensive treatment of periodontitis results in an improvement in serum lipid levels and a decrease in serum proinflammatory cytokine levels in patients with periodontitis and hyperlipidemia. These findings may contribute to present knowledge that periodontal therapy may be beneficial for individuals with hyperlipidemia.