Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice.
Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-A(y) mice.
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DOI：
10.2152/jmi.61.345
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
T. Hosaka;Sayaka Sasaga;Yukiko Yamasaka;Yoshitaka Nii;K. Edazawa;R. Tsutsumi;Emi Shuto;N. Okahisa
中科院分区：
文献类型：
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作者：
T. Hosaka;Sayaka Sasaga;Yukiko Yamasaka;Yoshitaka Nii;K. Edazawa;R. Tsutsumi;Emi Shuto;N. Okahisa
荞麦粉或蛋白质已被证明可以降低非糖尿病小鼠或大鼠的血清总胆固醇水平。然而，荞麦麸皮提取物（BBE）在糖尿病小鼠中的降脂作用尚未完全阐明。接受BBE治疗6周的KK-A（y）小鼠与对照（溶媒）小鼠相比，体重和肝脏重量降低。然而，在食物摄入方面没有显著差异。BBE治疗可防止肝脏甘油三酯蓄积并降低血清甘油三酯水平。此外，脂肪生成酶基因、脂肪酸合成酶、乙酰辅酶a氧化酶和硬脂酰辅酶a去饱和酶1的mRNA表达水平在BBE处理的小鼠中降低，但β-氧化酶基因的mRNA表达水平没有降低。在BBE处理的小鼠中，转录因子ChREBP和SREBP 1c（脂肪生成基因的转录本）的水平也降低。这些结果表明，BBE衍生物的长期治疗可能对2型糖尿病患者的高甘油三酯有有益的影响。
Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-A(y) mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.