Pentacyclic triterpenoids from the aerial parts of Lantana camara and their nematicidal activity
Pentacyclic triterpenoids from the aerial parts of Lantana camara and their nematicidal activity
复制标题
DOI：
10.1002/cbdv.200890173
复制
发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Ramzan, Musarrat
中科院分区：
文献类型：
--
作者：
Begum, Sabira;Zehra, Syeda Qamar;Ramzan, Musarrat
标题两个新的12-烯三萜类化合物：山茶酸（camarolic acid，1）和羊毛脂酸（lantriglylic acid，2）。从马缨丹地上部分分离得到沿着10个已知的三萜类化合物，即.骆驼蓬酸、马缨丹酸、马缨丹酸、pomolic acid、骆驼蓬酸、马缨丹酸、骆驼蓬苷、马缨丹素、骆驼蓬素和熊果酸。通过光谱研究和化学转化，新化合物被表征为3，25-环氧-3 α-羟基-22 β-{[（S）-3-羟基-2-亚甲基丁酰基]氧基}辛-12-烯-28-酸（1）和3，25-环氧-3 α-羟基-22 β-[（3-甲基丁-2-烯酰基）氧基]油酸-9（11），12-二烯-28-酸（2）。其中七种成分，即pomolic acid、lantanolic acid、lantoic acid、camarin。测试了马缨丹素、洋甘菊素和熊果酸对根结线虫南方根结线虫（Meloidogyneincognita）的杀线虫活性。Pomolic acid、lantanolic acid和lantoic acid在1 mg/ml浓度下24 h后显示100%死亡率，而camarin、lantacin、camarinin和ursolic acid在该浓度下48 h后显示100%死亡率。这些结果与用常规杀线虫剂呋喃丹（furadan）获得的结果相当（在1 mg/ml浓度下24小时后100%死亡率）。
Two new olean-12-ene triterpenoids, camarolic acid (1) and lantrigloylic acid (2). have been isolated from the aerial parts of Lantana camara, along with ten known triterpenes, namely. camaric acid, lantanolic acid, lantanilic acid, pomolic acid, camarinic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid. The new compounds have been characterized as 3,25-epoxy-3 alpha-hydroxy-22 beta-{[(S)-3-hydroxy-2-methylidenebutanoyl]oxy}olean-12-en-28-oic acid (1) and 3,25-epoxy-3 alpha-hydroxy-22 beta-[(3-methylbut-2-enoyl)oxy]olea-9(11).12-dien-28-oic acid (2) through spectroscopic studies and a chemical transformation. Seven of the constituents, namely pomolic acid, lantanolic acid, lantoic acid, camarin. lantacin, camarinin, and ursolic acid were tested for nematicidal activity against root-knot nematode Meloidogyne incognita. Pomolic acid, lantanolic acid, and lantoic acid showed 100% mortality at 1 mg/ml concentration after 24 h, while camarin, lantacin, camarinin, and ursolic acid exhibited 100% mortality at this concentration after 48 h. These results are comparable to those obtained with the conventional nematicide furadan (100% mortality at 1 mg/ml concentration after 24 h).