Crystal chemistry and solvent effects in polymorphic systems - Sulfathiazole
Crystal chemistry and solvent effects in polymorphic systems - Sulfathiazole
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DOI：
10.1039/a706669d
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发表时间：
1998-04-21
期刊：
影响因子：
--
通讯作者：
Docherty, R
中科院分区：
文献类型：
--
作者：
Blagden, N;Davey, RJ;Docherty, R
磺胺噻唑，一种化合物，形成四个已知的晶体结构，已被检查，以了解其多晶型。一个图形集的方法被用来分类的结构差异和相似性的多晶型物，其结果表明包装图案共同的四种结构。通过将该分析与实验形态学数据相结合，可以检查在该系统中观察到的多晶型外观的溶剂依赖性的起源。特别是，所观察到的氢键图案的每种形式和相关的成核和晶体生长的过程，从正丙醇，硝基甲烷，乙醇，水和氨溶液之间的可能的联系，已被认为是。
Sulfathiazole, a compound that forms four known crystal structures, has been examined with a view to understanding its polymorphism. A graph set approach was used to classify the structural differences and similarities of the polymorphs, the results of which indicated packing motifs common to three of the four structures. By combining this analysis with experimental morphological data, it has been possible to examine the origins of the observed solvent dependence of polymorph appearance in this system. In particular, the possible link between the observed hydrogen-bond motifs of each form and the associated processes of nucleation and crystal growth from n-propanol, nitromethane, ethanol, water and ammonia solution, have been considered.