A convenient route to alkaloid lipids: Application for the synthesis of a Leptophylline A analogue
A convenient route to alkaloid lipids: Application for the synthesis of a Leptophylline A analogue
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DOI：
10.1055/s-2002-19302
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发表时间：
2004-08
期刊：
影响因子：
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通讯作者：
S. Koulocheri;E. Pitsinos;S. Haroutounian
中科院分区：
文献类型：
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作者：
S. Koulocheri;E. Pitsinos;S. Haroutounian
报道了一种以手性2，3，6-三取代哌啶乙醛9为中间体合成生物碱脂质的方法。该合成路线的实用性在从D-葡萄糖醛开始的16个步骤和15%的总收率的不对称合成中被证明是在非天然类似物的决明子leptophyllla生物碱脂质，leptophyllin A。
A synthetic route for efficient access to alkaloid lipids, using the chiral 2,3,6-trisubstituted piperidine acetaldehyde 9 as an intermediate, is reported. The utility of the synthetic route was demonstrated in the asymmetric synthesis of an unnatural analogue of Cassia leptophylla alkaloid lipid, leptophyllin A, in 16 steps and 15% overall yield starting from D-glucal.