Cognitive reserve and brain reserve in prodromal Huntington's disease.
Cognitive reserve and brain reserve in prodromal Huntington's disease.
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DOI：
10.1017/s1355617713000507
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发表时间：
2013-08
影响因子：
2.6
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Bonner-Jackson, Aaron;Long, Jeffrey D.;Westervelt, Holly;Tremont, Geoffrey;Aylward, Elizabeth;Paulsen, Jane S.
亨廷顿病(HD)与认知能力下降和脑结构进行性形态改变有关。认知储备可能代表了一种机制，通过这种机制，与疾病相关的下降可能会被推迟或减缓。目前的研究考察了先兆(基因扩展阳性)HD患者的认知储备与认知功能和脑体积的纵向变化之间的关系。参与者是在Predicate-HD研究中登记的经过遗传确认的先兆HD患者。认知储备被计算为在一项词汇任务中的表现的合成，估计患病前的智力水平、职业状况和受教育年限。线性混合效应回归(LMER)被用来检验在大约6年的时间里4项认知测量和3个脑体积的纵向变化。对于那些估计最接近运动性疾病发作的人来说，较高的认知储备与其中一项认知测试(连线测试B部分)的变化速度较慢以及两个大脑结构(尾状核、壳核)的体积损失速度较慢显著相关。在那些估计距离运动性疾病发病更远的人中，没有观察到这种关系。我们的发现证明了认知储备与执行功能和某些大脑结构完整性的测量之间的关系。
Huntington disease (HD) is associated with decline in cognition and progressive morphological changes in brain structures. Cognitive reserve may represent a mechanism by which disease-related decline may be delayed or slowed. The current study examined the relationship between cognitive reserve and longitudinal change in cognitive functioning and brain volumes among prodromal (gene expansion-positive) HD individuals. Participants were genetically-confirmed individuals with prodromal HD enrolled in the PREDICT-HD study. Cognitive reserve was computed as the composite of performance on a lexical task estimating premorbid intellectual level, occupational status, and years of education. Linear mixed effects regression (LMER) was used to examine longitudinal changes on 4 cognitive measures and 3 brain volumes over approximately 6 years. Higher cognitive reserve was significantly associated with a slower rate of change on one cognitive measure (Trail Making Test, Part B) and slower rate of volume loss in two brain structures (caudate, putamen) for those estimated to be closest to motor disease onset. This relationship was not observed among those estimated to be further from motor disease onset. Our findings demonstrate a relationship between cognitive reserve and both a measure of executive functioning and integrity of certain brain structures in prodromal HD individuals.