INDUCED ANOVULATION AS TREATMENT OF PREMENSTRUAL TENSION SYNDROME - A DOUBLE-BLIND CROSSOVER STUDY WITH GNRH-AGONIST VERSUS PLACEBO
INDUCED ANOVULATION AS TREATMENT OF PREMENSTRUAL TENSION SYNDROME - A DOUBLE-BLIND CROSSOVER STUDY WITH GNRH-AGONIST VERSUS PLACEBO
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DOI：
10.3109/00016348809004191
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发表时间：
1988-01-01
影响因子：
4.3
通讯作者：
BACKSTROM, T
中科院分区：
文献类型：
--
作者：
HAMMARBACK, S;BACKSTROM, T
用gnrh激动剂buserelin鼻内给药，剂量为400.mu。G每日1次，诱导经前紧张综合征患者无排卵26例；23例患者完成了研究过程。设计是双盲和交叉的。对两个预处理、诊断周期进行每日症状评分，并持续6个周期或6个月。所使用的评定量表是先前描述的视觉模拟量表。在整个研究过程中，每周抽取一次血液样本进行雌二醇和黄体酮放射免疫测定。结果显示，与治疗前相比，安慰剂和gnrh激动剂均有较好的效果。然而，gnrh激动剂明显优于安慰剂。在治疗期结束时，患者仍然服用安慰剂，仍然表现出周期性症状变化，而在gnrh激动剂治疗期间，周期性变化已经消失。结果表明，黄体的一个因素必须参与周期性情绪变化的病因。结果还表明，通过gnrh激动剂抑制排卵是治疗经前紧张综合征的一种可能方法。
A treatment with the GnRH-agonist, buserelin, was given intranasally in a dosage of 400 .mu.g once daily, to induce anovulation in 26 women with premenstrual tension syndrome; 23 patients completed the study course. The design was double-blind and cross-over. Daily symptom ratings were made for two pretreatment, diagnostic cycles and continued for up to six cycles or 6 months. The rating scale used was an earlier described visual analogue scale. Blood samples for estradiol and progesterone radio-immunoassay were taken once weekly throughout the study. Results show beneficial effects of both placebo and GnRH-agonist, compared with the pretreatment situation. The GnRH-agonist was, however, significantly better than placebo. At the end of the treatment periods the patients while still taking placebo, still showed cyclical symptom changes, whereas during the GnRH-agonist treatment the cyclical changes had disappeared. The results indicate that a factor from the corpus luteum must be involved in the etiology of cyclical mood changes. The results also show that inhibition of ovulation by means of GnRH-agonists is one possible way to treat premenstrual tension syndrome.