CELL-SCAFFOLD INTERACTIONS IN THE BONE TISSUE ENGINEERING TRIAD
CELL-SCAFFOLD INTERACTIONS IN THE BONE TISSUE ENGINEERING TRIAD
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DOI：
10.22203/ecm.v026a09
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发表时间：
2013-07-01
影响因子：
3.1
通讯作者：
Schindeler, Aaron
中科院分区：
文献类型：
--
作者：
Murphy, Ciara M.;O'Brien, Fergal J.;Schindeler, Aaron
骨组织工程已成为组织工程和再生医学的前沿领域之一。骨组织工程的成功依赖于理解祖细胞、调节信号和用于递送它们的生物材料/支架之间的相互作用，也称为组织工程三元组。这篇综述将讨论这些基本成分的作用，特别关注细胞行为和支架结构特性之间的相互作用。在支架结构方面，最近的工作表明孔径可以影响细胞附着和细胞侵袭。此外，不同的材料可以施加不同的生物力学力，这可以以细胞类型特异性的方式深刻地影响细胞分化和迁移。了解这些相互作用将是至关重要的，以促进骨组织工程向临床应用的进展。
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver them otherwise known as the tissue engineering triad. This review will discuss the roles of these fundamental components with a specific focus on the interaction between cell behaviour and scaffold structural properties. In terms of scaffold architecture, recent work has shown that pore size can affect both cell attachment and cellular invasion. Moreover, different materials can exert different biomechanical forces, which can profoundly affect cellular differentiation and migration in a cell type specific manner. Understanding these interactions will be critical for enhancing the progress of bone tissue engineering towards clinical applications.