Inverse relation between stimulus intensity and seizure duration: Implications for ECT procedure
Inverse relation between stimulus intensity and seizure duration: Implications for ECT procedure
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DOI：
10.1097/00124509-200106000-00004
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发表时间：
2001-06-01
期刊：
影响因子：
2.5
通讯作者：
Kasper, S
中科院分区：
文献类型：
--
作者：
Frey, R;Heiden, A;Kasper, S
对根据年龄（平均年龄，52岁）、性别和诊断匹配的两组11名患者进行了电休克治疗（ECT）效果的回顾性分析。第1组根据年龄-剂量方案接受ECT治疗;第2组根据滴定法进行治疗。相对于癫痫发作阈值的较高剂量似乎缩短了癫痫发作持续时间。在第一次治疗时，刺激强度和癫痫发作持续时间之间的相关性是负的。在滴定组中，91 mC的初始平均电荷导致癫痫发作持续时间为51 s，而在年龄-剂量组中，尽管平均电荷较高（312 mC），但癫痫发作持续时间为31 a，明显较短。在ECT过程中，首先以低剂量（滴定）治疗，然后以初始阈值的2.5倍治疗的组癫痫发作持续时间缩短。高刺激强度代表适当的治疗，虽然它产生短暂的癫痫发作。因此。癫痫发作持续时间被证明是一个不可靠的指导有效的治疗。此外。对癫痫发作持续时间的关注导致老年人频繁接受高剂量再刺激。滴定法避免了电荷不足或过多，因为必须首先确定癫痫发作阈值。
A retrospective analysis of the effects of electroconvulsive therapy (ECT) was performed for two groups of 11 patients matched according to age (mean age, 52 years), sex, and diagnosis. Group 1 received ECT according to the age-dose protocol; group 2 was treated according to the titration method. A higher dose relative to the seizure threshold appeared to shorten the seizure duration. At the first treatment, the correlation between stimulus intensity and seizure duration was negative. In the titration group, the initial mean charge of 91 mC resulted in a seizure duration of 51 s, whereas in the age-dose group the seizure duration of 31 a was significantly shorter despite a higher mean charge of 312 mC. Seizure duration decreased during the ECT course in the group treated first at low dose (titrated) and then at 2.5 times the initial threshold. High stimulus intensity represented adequate treatment, although it produced short seizures. Thus. seizure duration proved to be an unreliable guideline for effective treatment. Furthermore. focus on seizure duration led to frequent high-dose restimulation in the elderly. The titration method obviates inadequate or excessive charges because the seizure threshold must first be determined.