THYROID ADAPTATION TO CHRONIC TETRAGLYCINE HYDROPERIODIDE WATER-PURIFICATION TABLET USE
THYROID ADAPTATION TO CHRONIC TETRAGLYCINE HYDROPERIODIDE WATER-PURIFICATION TABLET USE
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DOI：
10.1210/jc.80.1.220
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发表时间：
1995-01-01
影响因子：
5.8
通讯作者：
MCDERMOTT, MT
中科院分区：
文献类型：
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作者：
LEMAR, HJ;GEORGITIS, WJ;MCDERMOTT, MT
四甘氨酸氢高碘酸盐片通过释放8 mg游离碘/片来净化水。在8名健康志愿者中前瞻性地研究了每日4片英迪康连续3个月对甲状腺大小、功能和放射性碘摄取的影响。血清无机碘从2.7 μ g/dL升高至约100 μ g/dL。尿碘排泄量从治疗前的平均值0.276增加到40 mg/天，增加了150倍。7天后放射性碘摄取量低于2%，90天时所有受试者的放射性碘摄取量仍低于2%。平均血清T-4和T-3在7天后下降。T-4仍低于基线，而T-3在治疗期结束时已恢复。血清TSH和TSH对TRH的反应在7天后显著升高，并在3个月时保持升高。通过超声波测定的平均甲状腺体积增加了37%。未观察到甲状腺功能亢进或甲状腺功能减退。研究后平均7.1个月，7例受试者的平均甲状腺体积可用于重复测定，与基线值无差异。在正常受试者中，可逆的TSH依赖性甲状腺肿大发生在对日常使用四甘氨酸氢高碘酸水净化片的碘负荷的反应中。
Tetraglycine hydroperiodide tablets purify water by liberating 8 mg free iodine/tablet. The effects of ingesting four tablets daily for 3 months on thyroid size, function, and radioactive iodine uptake were studied prospectively in eight healthy volunteers. Serum inorganic iodide increased from 2.7 to approldmately 100 mu g/dL. Urinary iodide excretion rose 150-fold from a pretreatment mean of 0.276 to 40 mg/day. Radioactive iodine uptake was less than 2% after 7 days and remained below 2% in all subjects at 90 days. Mean serum T-4 and T-3 declined after 7 days. T-4 remained below baseline, whereas T-3 had recovered by the end of the treatment period. Serum TSH and the TSH response to TRH rose significantly after 7 days and remained elevated at 3 months. The average thyroid volume, determined by ultrasound, increased by 37%. Neither hyperthyroidism nor hypothyroidism was observed. The mean thyroid volume in seven subjects available for repeat determinations an average of 7.1 months after the study was not different from the baseline value. In normal subjects, a reversible TSH-dependent thyroid enlargement occurs in response to the iodine load from daily use of tetraglycine hydroperiodide water purification tablets.